Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease

Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease

Zika virus (ZIKV) NS2B-NS3 protease is a validated antiviral target as it is essential for maturation of viral proteins. However, its negatively charged active site hinders the development of orthosteric small-molecule inhibitors. Fragment-based drug discovery (FBDD) is a powerful tool to generate n...

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Bibliographic Details
Main Authors: Quek, Jun Ping, Liu, Shuang, Zhang, Zhenzhen, Li, Yan, Ng, Elizabeth Yihui, Loh, Ying Ru, Hung, Alvin W., Luo, Dahai, Kang, CongBao
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Zika Virus
Fragment-based Drug Discovery
Online Access:https://hdl.handle.net/10356/140769

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