Recent advances of membrane-cloaked nanoplatforms for biomedical applications
In terms of the extremely small size and large specific surface area, nanomaterials often exhibit unusual physical and chemical properties, which have recently attracted considerable attention in bionanotechnology and nanomedicine. Currently, the extensive usage of nanotechnology in medicine holds g...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/140819 |
| _version_ | 1811691475221610496 |
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| author | Ai, Xiangzhao Hu, Ming Wang, Zhimin Zhang, Wenmin Li, Juan Yang, Huanghao Lin, Jun Xing, Bengang |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Ai, Xiangzhao Hu, Ming Wang, Zhimin Zhang, Wenmin Li, Juan Yang, Huanghao Lin, Jun Xing, Bengang |
| author_sort | Ai, Xiangzhao |
| collection | NTU |
| description | In terms of the extremely small size and large specific surface area, nanomaterials often exhibit unusual physical and chemical properties, which have recently attracted considerable attention in bionanotechnology and nanomedicine. Currently, the extensive usage of nanotechnology in medicine holds great potential for precise diagnosis and effective therapeutics of various human diseases in clinical practice. However, a detailed understanding regarding how nanomedicine interacts with the intricate environment in complex living systems remains a pressing and challenging goal. Inspired by the diversified membrane structures and functions of natural prototypes, research activities on biomimetic and bioinspired membranes, especially for those cloaking nanosized platforms, have increased exponentially. By taking advantage of the flexible synthesis and multiple functionality of nanomaterials, a variety of unique nanostructures including inorganic nanocrystals and organic polymers have been widely devised to substantially integrate with intrinsic biomoieties such as lipids, glycans, and even cell and bacteria membrane components, which endow these abiotic nanomaterials with specific biological functionalities for the purpose of detailed investigation of the complicated interactions and activities of nanomedicine in living bodies, including their immune response activation, phagocytosis escape, and subsequent clearance from vascular system. In this review, we summarize the strategies established recently for the development of biomimetic membrane-cloaked nanoplatforms derived from inherent host cells (e.g., erythrocytes, leukocytes, platelets, and exosomes) and invasive pathogens (e.g., bacteria and viruses), mainly attributed to their versatile membrane properties in biological fluids. Meanwhile, the promising biomedical applications based on nanoplatforms inspired by diverse moieties, such as selective drug delivery in targeted sites and effective vaccine development for disease prevention, have also been outlined. Finally, the potential challenges and future prospects of the biomimetic membrane-cloaked nanoplatforms are also discussed. |
| first_indexed | 2024-10-01T06:20:29Z |
| format | Journal Article |
| id | ntu-10356/140819 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:20:29Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1408192020-06-02T05:42:25Z Recent advances of membrane-cloaked nanoplatforms for biomedical applications Ai, Xiangzhao Hu, Ming Wang, Zhimin Zhang, Wenmin Li, Juan Yang, Huanghao Lin, Jun Xing, Bengang School of Physical and Mathematical Sciences Science::Chemistry Immunology Vesicles In terms of the extremely small size and large specific surface area, nanomaterials often exhibit unusual physical and chemical properties, which have recently attracted considerable attention in bionanotechnology and nanomedicine. Currently, the extensive usage of nanotechnology in medicine holds great potential for precise diagnosis and effective therapeutics of various human diseases in clinical practice. However, a detailed understanding regarding how nanomedicine interacts with the intricate environment in complex living systems remains a pressing and challenging goal. Inspired by the diversified membrane structures and functions of natural prototypes, research activities on biomimetic and bioinspired membranes, especially for those cloaking nanosized platforms, have increased exponentially. By taking advantage of the flexible synthesis and multiple functionality of nanomaterials, a variety of unique nanostructures including inorganic nanocrystals and organic polymers have been widely devised to substantially integrate with intrinsic biomoieties such as lipids, glycans, and even cell and bacteria membrane components, which endow these abiotic nanomaterials with specific biological functionalities for the purpose of detailed investigation of the complicated interactions and activities of nanomedicine in living bodies, including their immune response activation, phagocytosis escape, and subsequent clearance from vascular system. In this review, we summarize the strategies established recently for the development of biomimetic membrane-cloaked nanoplatforms derived from inherent host cells (e.g., erythrocytes, leukocytes, platelets, and exosomes) and invasive pathogens (e.g., bacteria and viruses), mainly attributed to their versatile membrane properties in biological fluids. Meanwhile, the promising biomedical applications based on nanoplatforms inspired by diverse moieties, such as selective drug delivery in targeted sites and effective vaccine development for disease prevention, have also been outlined. Finally, the potential challenges and future prospects of the biomimetic membrane-cloaked nanoplatforms are also discussed. 2020-06-02T05:42:25Z 2020-06-02T05:42:25Z 2018 Journal Article Ai, X., Hu, M., Wang, Z., Zhang, W., Li, J., Yang, H., . . . Xing, B. (2018). Recent advances of membrane-cloaked nanoplatforms for biomedical applications. Bioconjugate Chemistry, 29(4), 838-851. doi:10.1021/acs.bioconjchem.8b00103 1043-1802 https://hdl.handle.net/10356/140819 10.1021/acs.bioconjchem.8b00103 29509403 2-s2.0-85045543011 4 29 838 851 en Bioconjugate Chemistry This document is the Accepted Manuscript version of a Published Work that appeared in final form in Bioconjugate Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.bioconjchem.8b00103 |
| spellingShingle | Science::Chemistry Immunology Vesicles Ai, Xiangzhao Hu, Ming Wang, Zhimin Zhang, Wenmin Li, Juan Yang, Huanghao Lin, Jun Xing, Bengang Recent advances of membrane-cloaked nanoplatforms for biomedical applications |
| title | Recent advances of membrane-cloaked nanoplatforms for biomedical applications |
| title_full | Recent advances of membrane-cloaked nanoplatforms for biomedical applications |
| title_fullStr | Recent advances of membrane-cloaked nanoplatforms for biomedical applications |
| title_full_unstemmed | Recent advances of membrane-cloaked nanoplatforms for biomedical applications |
| title_short | Recent advances of membrane-cloaked nanoplatforms for biomedical applications |
| title_sort | recent advances of membrane cloaked nanoplatforms for biomedical applications |
| topic | Science::Chemistry Immunology Vesicles |
| url | https://hdl.handle.net/10356/140819 |
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