Does oxidative stress contribute to adverse outcomes in HIV-associated TB?
In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/141007 |
| _version_ | 1826128809591570432 |
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| author | Yew, Wing-Wai Chan, Denise Puichung Singhal, Amit Zhang, Ying Lee, Shui-Shan |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Yew, Wing-Wai Chan, Denise Puichung Singhal, Amit Zhang, Ying Lee, Shui-Shan |
| author_sort | Yew, Wing-Wai |
| collection | NTU |
| description | In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients. |
| first_indexed | 2024-10-01T07:30:57Z |
| format | Journal Article |
| id | ntu-10356/141007 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:30:57Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1410072020-06-03T06:52:07Z Does oxidative stress contribute to adverse outcomes in HIV-associated TB? Yew, Wing-Wai Chan, Denise Puichung Singhal, Amit Zhang, Ying Lee, Shui-Shan Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Oxidative Stress HIV In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2020-06-03T06:52:07Z 2020-06-03T06:52:07Z 2018 Journal Article Yew, W.-W., Chan, D. P., Singhal, A., Zhang, Y., & Lee, S.-S. (2018). Does oxidative stress contribute to adverse outcomes in HIV-associated TB? Journal of Antimicrobial Chemotherapy, 73(5), 1117-1120. doi:10.1093/jac/dkx509 0305-7453 https://hdl.handle.net/10356/141007 10.1093/jac/dkx509 29325139 2-s2.0-85047020108 5 73 1117 1120 en Journal of Antimicrobial Chemotherapy © 2018 The Author(s) (published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy). All rights reserved. |
| spellingShingle | Science::Medicine Oxidative Stress HIV Yew, Wing-Wai Chan, Denise Puichung Singhal, Amit Zhang, Ying Lee, Shui-Shan Does oxidative stress contribute to adverse outcomes in HIV-associated TB? |
| title | Does oxidative stress contribute to adverse outcomes in HIV-associated TB? |
| title_full | Does oxidative stress contribute to adverse outcomes in HIV-associated TB? |
| title_fullStr | Does oxidative stress contribute to adverse outcomes in HIV-associated TB? |
| title_full_unstemmed | Does oxidative stress contribute to adverse outcomes in HIV-associated TB? |
| title_short | Does oxidative stress contribute to adverse outcomes in HIV-associated TB? |
| title_sort | does oxidative stress contribute to adverse outcomes in hiv associated tb |
| topic | Science::Medicine Oxidative Stress HIV |
| url | https://hdl.handle.net/10356/141007 |
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