The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines
Intramolecular endo-aza-Michael additions are categorised in various ways. Firstly whether they are single or double reactions, secondly whether they are endo- or exo-activated (or both), thirdly whether the Michael acceptor is an alkene or an alkyne, and finally whether the product is a six or a fi...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/141239 |
| _version_ | 1826125418749493248 |
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| author | Bates, Roderick Wayland Ko, Weiting Barát, Viktor |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Bates, Roderick Wayland Ko, Weiting Barát, Viktor |
| author_sort | Bates, Roderick Wayland |
| collection | NTU |
| description | Intramolecular endo-aza-Michael additions are categorised in various ways. Firstly whether they are single or double reactions, secondly whether they are endo- or exo-activated (or both), thirdly whether the Michael acceptor is an alkene or an alkyne, and finally whether the product is a six or a five membered ring. Reactions in the various categories are illustrated by syntheses of piperidines and pyrrolidines, including a range of natural products. The question of the stereochemical outcome and whether it is understood is discussed. |
| first_indexed | 2024-10-01T06:36:00Z |
| format | Journal Article |
| id | ntu-10356/141239 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:36:00Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1412392023-02-28T19:44:38Z The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines Bates, Roderick Wayland Ko, Weiting Barát, Viktor School of Physical and Mathematical Sciences Science::Chemistry Aza-Michael Addition Synthesis (Chemical) Intramolecular endo-aza-Michael additions are categorised in various ways. Firstly whether they are single or double reactions, secondly whether they are endo- or exo-activated (or both), thirdly whether the Michael acceptor is an alkene or an alkyne, and finally whether the product is a six or a five membered ring. Reactions in the various categories are illustrated by syntheses of piperidines and pyrrolidines, including a range of natural products. The question of the stereochemical outcome and whether it is understood is discussed. MOE (Min. of Education, S’pore) Accepted version 2020-06-05T04:27:31Z 2020-06-05T04:27:31Z 2020 Journal Article Bates, R. W., Ko, W., & Barát, V. (2020). The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines. Organic & Biomolecular Chemistry, 18(5), 810-829. doi:10.1039/C9OB02388G 1477-0520 https://hdl.handle.net/10356/141239 10.1039/C9OB02388G 5 18 810 829 en Organic & Biomolecular Chemistry © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Organic & Biomolecular Chemistry and is made available with permission of The Royal Society of Chemistry. application/pdf |
| spellingShingle | Science::Chemistry Aza-Michael Addition Synthesis (Chemical) Bates, Roderick Wayland Ko, Weiting Barát, Viktor The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines |
| title | The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines |
| title_full | The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines |
| title_fullStr | The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines |
| title_full_unstemmed | The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines |
| title_short | The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines |
| title_sort | endo aza michael addition in the synthesis of piperidines and pyrrolidines |
| topic | Science::Chemistry Aza-Michael Addition Synthesis (Chemical) |
| url | https://hdl.handle.net/10356/141239 |
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