Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering
In the past few years, with the support of AcRF Fund, our team has exploited in several emerging areas of bio-nanosciences and biochemical engineering. Most biological processes leading to cellular functions and physiological regulations are driven by molecular interactions at the nano-scale regi...
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| Format: | Research Report |
| Language: | English |
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2008
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| Online Access: | http://hdl.handle.net/10356/14163 |
| _version_ | 1826116773591646208 |
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| author | Chan, Vincent. |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Chan, Vincent. |
| author_sort | Chan, Vincent. |
| collection | NTU |
| description | In the past few years, with the support of AcRF Fund, our team has exploited in several
emerging areas of bio-nanosciences and biochemical engineering. Most biological
processes leading to cellular functions and physiological regulations are driven by
molecular interactions at the nano-scale regime. A good example is the specific
recognition between protein and proteoglycan receptors embedded in cell membrane
matrix and other biomolecules immobilized on extracellular matrix that trigger the signal
transduction cascades of cells and tissues. Our work supported by AcRF fund has been
mainly focused on the elucidation of bio-interfacial phenomena that are involved in cell
therapeutics device and drug delivery systems. However, it is currently impossible to
fully engineer cellular processes from the first principle based on molecular interactions
due to gap between biology and nanotechology. We intend to fill this gap by
interrogating the biophysical events involved in membrane-polymer interaction,
biological adhesion, tissue engineering and cellular fluid mechanics. In the area of model
membrane adhesion, we have elucidated the role of thermotropic transition, acyl chain
mismatch, surface chemistry on the deformation degree and adhesion energy of
unilamellar vesicles. In our tissue engineering work, biological ligands are synthesized
and then covalently linked to the extracellular matrix for providing highly tailored
biological signals for hepatocyte culture. Then C-RICM and fluorescence microscopy
are applied to probe the biomechanical responses and cytoskeletal dynamics of the
attached cells. |
| first_indexed | 2024-10-01T04:16:52Z |
| format | Research Report |
| id | ntu-10356/14163 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:16:52Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/141632023-03-03T15:30:30Z Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering Chan, Vincent. School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biotechnology In the past few years, with the support of AcRF Fund, our team has exploited in several emerging areas of bio-nanosciences and biochemical engineering. Most biological processes leading to cellular functions and physiological regulations are driven by molecular interactions at the nano-scale regime. A good example is the specific recognition between protein and proteoglycan receptors embedded in cell membrane matrix and other biomolecules immobilized on extracellular matrix that trigger the signal transduction cascades of cells and tissues. Our work supported by AcRF fund has been mainly focused on the elucidation of bio-interfacial phenomena that are involved in cell therapeutics device and drug delivery systems. However, it is currently impossible to fully engineer cellular processes from the first principle based on molecular interactions due to gap between biology and nanotechology. We intend to fill this gap by interrogating the biophysical events involved in membrane-polymer interaction, biological adhesion, tissue engineering and cellular fluid mechanics. In the area of model membrane adhesion, we have elucidated the role of thermotropic transition, acyl chain mismatch, surface chemistry on the deformation degree and adhesion energy of unilamellar vesicles. In our tissue engineering work, biological ligands are synthesized and then covalently linked to the extracellular matrix for providing highly tailored biological signals for hepatocyte culture. Then C-RICM and fluorescence microscopy are applied to probe the biomechanical responses and cytoskeletal dynamics of the attached cells. 2008-11-05T07:14:32Z 2008-11-05T07:14:32Z 2005 2005 Research Report http://hdl.handle.net/10356/14163 en 133 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Chemical engineering::Biotechnology Chan, Vincent. Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| title | Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| title_full | Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| title_fullStr | Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| title_full_unstemmed | Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| title_short | Interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| title_sort | interfacial phenomena and biological recognition of proteins for biomaterial design and tissue engineering |
| topic | DRNTU::Engineering::Chemical engineering::Biotechnology |
| url | http://hdl.handle.net/10356/14163 |
| work_keys_str_mv | AT chanvincent interfacialphenomenaandbiologicalrecognitionofproteinsforbiomaterialdesignandtissueengineering |