Rational engineering and characterization of an mAb that neutralizes Zika virus by targeting a mutationally constrained quaternary epitope

Rational engineering and characterization of an mAb that neutralizes Zika virus by targeting a mutationally constrained quaternary epitope

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Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for co...

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Bibliographic Details
Main Authors: Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Antibody
Therapeutic
Online Access:https://hdl.handle.net/10356/141659
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