A strategy for strong interface bonding by 3D bioprinting of oppositely charged κ-carrageenan and gelatin hydrogels
A promising approach for improving the interfacial bonding of a three-dimensionally (3D) printed multilayered structure has been investigated by taking advantage of the electrostatic interactions between two hydrogels with oppositely charges. Here, two hydrogels namely gelatin and κ-carrageenan, whi...
| Main Authors: | , , |
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| 其他作者: | |
| 格式: | Journal Article |
| 语言: | English |
| 出版: |
2020
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| 主题: | |
| 在线阅读: | https://hdl.handle.net/10356/141763 |
| 总结: | A promising approach for improving the interfacial bonding of a three-dimensionally (3D) printed multilayered structure has been investigated by taking advantage of the electrostatic interactions between two hydrogels with oppositely charges. Here, two hydrogels namely gelatin and κ-carrageenan, which are the cationic and anionic hydrogels respectively, are used. It is found that the interfacial bonding strength between these two oppositely charged hydrogels is significantly higher than that of a bilayered gelatin or a bilayered κ-carrageenan. The bioprinted multilayered κ-carrageenan-gelatin hydrogel construct demonstrates a very good biocompatibility and a good structure integrity at 37 °C. Our strategy also overcomes the limitation of using gelatin for bio-fabrication at 37 °C, without further post crosslinking. |
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