PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction
Background: As the only arterial structure of which two main arteries merged into one, the vertebro-basilar (VA-BA) system is one of the favorite sites of cerebral atherosclerotic plaques. The aim of this study was to investigate the detailed hemodynamics characteristics in the VA-BA system. Methods...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/142016 |
| _version_ | 1811696686757576704 |
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| author | Zhu, Guangyu Wei, Yuan Yuan, Qi Yang, Jian Yeo, Joon Hock |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Zhu, Guangyu Wei, Yuan Yuan, Qi Yang, Jian Yeo, Joon Hock |
| author_sort | Zhu, Guangyu |
| collection | NTU |
| description | Background: As the only arterial structure of which two main arteries merged into one, the vertebro-basilar (VA-BA) system is one of the favorite sites of cerebral atherosclerotic plaques. The aim of this study was to investigate the detailed hemodynamics characteristics in the VA-BA system. Methods: A scale-up subject-specific flow phantom of VA-BA system was fabricated based on the computed tomography angiography (CTA) scanning images of a healthy adult. Flow fields in eight axial planes and six radial planes were measured and analyzed by using particle image velocimetry (PIV) under steady flow conditions of Re=300, Re=500. A water–glycerin mixture was used as the working fluid. Results: The flow in the current model exhibited highly three-dimensional characteristics. The confluence of VAs flow formed bimodal velocity distribution near the confluence apex. Due to the asymmetrical structural configuration, the bimodal velocity profile skewed towards left, and sharper peaks were observed under higher Reynolds condition. Secondary flow characterized by two vortices formed in the radial planes where 10 mm downstream the confluence apex and persists along the BA under both Reynolds numbers. The strength of secondary flow under Re=500 is around 8% higher than that under Re=300, and decayed nonlinearly along the flow direction. In addition, a low momentum recirculation region induced by boundary layer separation was observed near the confluence apex. The wall shear stress (WSS) in the recirculation area was found to be lower than 0.4 Pa. This region coincides well with the preferential site of vascular lesions in the VA-BA system. Conclusions: This preliminary study verified that the subject-specific in-vitro experiment is capable of reflecting the detailed flow features in the VA-BA system. The findings from this study may help to expand the understanding of the hemodynamics in the VA-BA system, and further clarifying the mechanism that underlying the localization of vascular lesions. |
| first_indexed | 2024-10-01T07:43:19Z |
| format | Journal Article |
| id | ntu-10356/142016 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:43:19Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1420162023-03-04T17:21:35Z PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction Zhu, Guangyu Wei, Yuan Yuan, Qi Yang, Jian Yeo, Joon Hock School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering PIV In-vitro Background: As the only arterial structure of which two main arteries merged into one, the vertebro-basilar (VA-BA) system is one of the favorite sites of cerebral atherosclerotic plaques. The aim of this study was to investigate the detailed hemodynamics characteristics in the VA-BA system. Methods: A scale-up subject-specific flow phantom of VA-BA system was fabricated based on the computed tomography angiography (CTA) scanning images of a healthy adult. Flow fields in eight axial planes and six radial planes were measured and analyzed by using particle image velocimetry (PIV) under steady flow conditions of Re=300, Re=500. A water–glycerin mixture was used as the working fluid. Results: The flow in the current model exhibited highly three-dimensional characteristics. The confluence of VAs flow formed bimodal velocity distribution near the confluence apex. Due to the asymmetrical structural configuration, the bimodal velocity profile skewed towards left, and sharper peaks were observed under higher Reynolds condition. Secondary flow characterized by two vortices formed in the radial planes where 10 mm downstream the confluence apex and persists along the BA under both Reynolds numbers. The strength of secondary flow under Re=500 is around 8% higher than that under Re=300, and decayed nonlinearly along the flow direction. In addition, a low momentum recirculation region induced by boundary layer separation was observed near the confluence apex. The wall shear stress (WSS) in the recirculation area was found to be lower than 0.4 Pa. This region coincides well with the preferential site of vascular lesions in the VA-BA system. Conclusions: This preliminary study verified that the subject-specific in-vitro experiment is capable of reflecting the detailed flow features in the VA-BA system. The findings from this study may help to expand the understanding of the hemodynamics in the VA-BA system, and further clarifying the mechanism that underlying the localization of vascular lesions. Published version 2020-06-15T02:39:48Z 2020-06-15T02:39:48Z 2019 Journal Article Zhu, G., Wei, Y., Yuan, Q., Yang, J., & Yeo, J. H. (2019). PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction. BioMedical Engineering Online, 18(1), 93-. doi:10.1186/s12938-019-0711-9 1475-925X https://hdl.handle.net/10356/142016 10.1186/s12938-019-0711-9 31492145 2-s2.0-85071896458 1 18 en BioMedical Engineering Online © 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. application/pdf |
| spellingShingle | Engineering::Mechanical engineering PIV In-vitro Zhu, Guangyu Wei, Yuan Yuan, Qi Yang, Jian Yeo, Joon Hock PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction |
| title | PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction |
| title_full | PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction |
| title_fullStr | PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction |
| title_full_unstemmed | PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction |
| title_short | PIV investigation of the flow fields in subject-specific vertebro-basilar (VA-BA) junction |
| title_sort | piv investigation of the flow fields in subject specific vertebro basilar va ba junction |
| topic | Engineering::Mechanical engineering PIV In-vitro |
| url | https://hdl.handle.net/10356/142016 |
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