In situ organ-specific vascularization in tissue engineering
Other than a few avascular tissues, almost all human tissues are connected to the systemic circulation via blood vessels that promote metabolism and function. Accordingly, engineered vascularization is a vital goal in tissue engineering for regenerative medicine. Endothelial cells (ECs) play a centr...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/142045 |
| _version_ | 1811689554078334976 |
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| author | Fu, Jiayin Wang, Dong-An |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Fu, Jiayin Wang, Dong-An |
| author_sort | Fu, Jiayin |
| collection | NTU |
| description | Other than a few avascular tissues, almost all human tissues are connected to the systemic circulation via blood vessels that promote metabolism and function. Accordingly, engineered vascularization is a vital goal in tissue engineering for regenerative medicine. Endothelial cells (ECs) play a central role in vascularization with two significant specificities: physical interfaces between vascular stroma and blood, and phenotypic organ-specificity. Biomaterial scaffolding technologies that address these unique properties of ECs have been developed to promote the vascularization of various engineered tissues, and these have advanced from mimicking vascular architectures ex situ towards promoting spontaneous angiogenic remodeling in situ. Simultaneously, endothelial progenitor cells (EPCs) and organ-specific ECs are attracting more and more attention with the increasing awareness of the diversity of ECs in different organs. |
| first_indexed | 2024-10-01T05:49:57Z |
| format | Journal Article |
| id | ntu-10356/142045 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:49:57Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1420452020-06-15T04:55:18Z In situ organ-specific vascularization in tissue engineering Fu, Jiayin Wang, Dong-An School of Chemical and Biomedical Engineering Engineering::Chemical engineering Tissue Engineering Endothelial Cells Other than a few avascular tissues, almost all human tissues are connected to the systemic circulation via blood vessels that promote metabolism and function. Accordingly, engineered vascularization is a vital goal in tissue engineering for regenerative medicine. Endothelial cells (ECs) play a central role in vascularization with two significant specificities: physical interfaces between vascular stroma and blood, and phenotypic organ-specificity. Biomaterial scaffolding technologies that address these unique properties of ECs have been developed to promote the vascularization of various engineered tissues, and these have advanced from mimicking vascular architectures ex situ towards promoting spontaneous angiogenic remodeling in situ. Simultaneously, endothelial progenitor cells (EPCs) and organ-specific ECs are attracting more and more attention with the increasing awareness of the diversity of ECs in different organs. 2020-06-15T04:55:18Z 2020-06-15T04:55:18Z 2018 Journal Article Fu, J., & Wang, D.-A. (2018). In situ organ-specific vascularization in tissue engineering. Trends in biotechnology, 36(8), 834-849. doi:10.1016/j.tibtech.2018.02.012 0167-7799 https://hdl.handle.net/10356/142045 10.1016/j.tibtech.2018.02.012 29555346 2-s2.0-85043994184 8 36 834 849 en Trends in biotechnology © 2018 Elsevier Ltd. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Tissue Engineering Endothelial Cells Fu, Jiayin Wang, Dong-An In situ organ-specific vascularization in tissue engineering |
| title | In situ organ-specific vascularization in tissue engineering |
| title_full | In situ organ-specific vascularization in tissue engineering |
| title_fullStr | In situ organ-specific vascularization in tissue engineering |
| title_full_unstemmed | In situ organ-specific vascularization in tissue engineering |
| title_short | In situ organ-specific vascularization in tissue engineering |
| title_sort | in situ organ specific vascularization in tissue engineering |
| topic | Engineering::Chemical engineering Tissue Engineering Endothelial Cells |
| url | https://hdl.handle.net/10356/142045 |
| work_keys_str_mv | AT fujiayin insituorganspecificvascularizationintissueengineering AT wangdongan insituorganspecificvascularizationintissueengineering |