Top-down control : a unified principle of cortical learning
Cognitive control of the brain flexibly maps incoming sensory information onto execution of actions appropriate for the current goal. Learning is a process that enables the brain to estimate current states of the world by extracting its spatiotemporal structure and generate goal-directed motor outpu...
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/142104 |
| _version_ | 1826123761410113536 |
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| author | Makino, Hiroshi |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Makino, Hiroshi |
| author_sort | Makino, Hiroshi |
| collection | NTU |
| description | Cognitive control of the brain flexibly maps incoming sensory information onto execution of actions appropriate for the current goal. Learning is a process that enables the brain to estimate current states of the world by extracting its spatiotemporal structure and generate goal-directed motor outputs through selective association of events or movement refinement. Accumulating evidence suggests that top-down control from higher-order brain areas modulates downstream neural activity and changes local computations that are critical for the execution of learned behavior. Recent technological advances in multi-site recordings and optogenetic approaches are beginning to reveal more direct evidence of top-down cognitive control by monitoring and perturbing activity of top-down inputs and observing its causal consequences on behavior and downstream neural dynamics. Here I highlight that learning-related changes in neural circuits in distinct domains of learning converge onto a unified principle; namely recruitment of top-down control whether it involves sensory, motor or offline learning. Recruitment of top-down control may reflect experience-dependent adaptation and integration of internal models for refined state estimation and goal-directed optimal behavior. |
| first_indexed | 2024-10-01T06:09:55Z |
| format | Journal Article |
| id | ntu-10356/142104 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:09:55Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1421042020-06-16T02:05:21Z Top-down control : a unified principle of cortical learning Makino, Hiroshi Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Top-down Control Perceptual Learning Cognitive control of the brain flexibly maps incoming sensory information onto execution of actions appropriate for the current goal. Learning is a process that enables the brain to estimate current states of the world by extracting its spatiotemporal structure and generate goal-directed motor outputs through selective association of events or movement refinement. Accumulating evidence suggests that top-down control from higher-order brain areas modulates downstream neural activity and changes local computations that are critical for the execution of learned behavior. Recent technological advances in multi-site recordings and optogenetic approaches are beginning to reveal more direct evidence of top-down cognitive control by monitoring and perturbing activity of top-down inputs and observing its causal consequences on behavior and downstream neural dynamics. Here I highlight that learning-related changes in neural circuits in distinct domains of learning converge onto a unified principle; namely recruitment of top-down control whether it involves sensory, motor or offline learning. Recruitment of top-down control may reflect experience-dependent adaptation and integration of internal models for refined state estimation and goal-directed optimal behavior. 2020-06-16T02:05:21Z 2020-06-16T02:05:21Z 2019 Journal Article Makino, H. (2019). Top-down control : a unified principle of cortical learning. Neuroscience research, 141, 23-28. doi:10.1016/j.neures.2018.08.004 0168-0102 https://hdl.handle.net/10356/142104 10.1016/j.neures.2018.08.004 30125609 2-s2.0-85052064778 141 23 28 en Neuroscience research © 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved. |
| spellingShingle | Science::Medicine Top-down Control Perceptual Learning Makino, Hiroshi Top-down control : a unified principle of cortical learning |
| title | Top-down control : a unified principle of cortical learning |
| title_full | Top-down control : a unified principle of cortical learning |
| title_fullStr | Top-down control : a unified principle of cortical learning |
| title_full_unstemmed | Top-down control : a unified principle of cortical learning |
| title_short | Top-down control : a unified principle of cortical learning |
| title_sort | top down control a unified principle of cortical learning |
| topic | Science::Medicine Top-down Control Perceptual Learning |
| url | https://hdl.handle.net/10356/142104 |
| work_keys_str_mv | AT makinohiroshi topdowncontrolaunifiedprincipleofcorticallearning |