Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

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Chemical modification of transcripts with 5' caps occurs in all organisms. Here, we report a systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an organism's cap epitranscriptome. The method was piloted with 21 canonical caps-m7GpppN, m7GpppNm, GpppN, G...

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Bibliographic Details
Main Authors: Wang, Jin, Chew, Alvin Bing Liang, Lai, Yong, Dong, Hongping, Xu, Luang, Balamkundu, Seetharamsingh, Cai, Maggie Weiling, Cui, Liang, Liu, Chuan Fa, Fu, Xin-Yuan, Lin, Zhenguo, Shi, Pei-Yong, Lu, Timothy K., Luo, Dahai, Jaffrey, Samie R., Dedon, Peter C.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Medicine
RNA Characterisation and Manipulation
Mass Spectrometry-based Technique
Online Access:https://hdl.handle.net/10356/142174
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