Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds
Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose‐black phosphorus nanosheets, (Gal‐BP NSs) as a delivery platform for synergistic antibiotic (ka...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/142368 |
| _version_ | 1826123096136876032 |
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| author | Guo, Zhong He, Jing-Xi Mahadevegowda, Surendra Hittanahalli Kho, Shu Hui Chan-Park, Mary B. Liu, Xue-Wei |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Guo, Zhong He, Jing-Xi Mahadevegowda, Surendra Hittanahalli Kho, Shu Hui Chan-Park, Mary B. Liu, Xue-Wei |
| author_sort | Guo, Zhong |
| collection | NTU |
| description | Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose‐black phosphorus nanosheets, (Gal‐BP NSs) as a delivery platform for synergistic antibiotic (kanamycin, Kana) and photothermal treatments against the Gram‐negative microbial strain, Pseudomonas aeruginosa PAO1 (PAO1) is reported. Gal‐BP NSs@Kana can actively target PAO1 and release kanamycin into the bacterial cytoplasm upon near‐infrared laser irradiation. This strategy kills most of the PAO1 through a simultaneous burst of intracellular kanamycin release and photothermal treatment. Comparable antibacterial activities of Gal‐BP NSs@Kana are observed within in vivo mouse models at their wound sites. In addition, this platform accelerates wound healing from PAO1 infection via promotion of neoangiogenesis and collagen production at the wound sites. This work demonstrates the material properties of Gal‐BP NS in fighting bacterial infections and in the treatment of wound healing. |
| first_indexed | 2024-10-01T05:59:02Z |
| format | Journal Article |
| id | ntu-10356/142368 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:59:02Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1423682023-02-28T19:47:09Z Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds Guo, Zhong He, Jing-Xi Mahadevegowda, Surendra Hittanahalli Kho, Shu Hui Chan-Park, Mary B. Liu, Xue-Wei School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Science::Chemistry Active Targeting Bacteria Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose‐black phosphorus nanosheets, (Gal‐BP NSs) as a delivery platform for synergistic antibiotic (kanamycin, Kana) and photothermal treatments against the Gram‐negative microbial strain, Pseudomonas aeruginosa PAO1 (PAO1) is reported. Gal‐BP NSs@Kana can actively target PAO1 and release kanamycin into the bacterial cytoplasm upon near‐infrared laser irradiation. This strategy kills most of the PAO1 through a simultaneous burst of intracellular kanamycin release and photothermal treatment. Comparable antibacterial activities of Gal‐BP NSs@Kana are observed within in vivo mouse models at their wound sites. In addition, this platform accelerates wound healing from PAO1 infection via promotion of neoangiogenesis and collagen production at the wound sites. This work demonstrates the material properties of Gal‐BP NS in fighting bacterial infections and in the treatment of wound healing. ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Accepted version 2020-06-19T07:36:33Z 2020-06-19T07:36:33Z 2020 Journal Article Guo, Z., He, J.-X., Mahadevegowda, S. H., Kho, S. H., Chan‐Park, M. B., & Liu, X.-W. (2020). Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds. Advanced Healthcare Materials, 9(10), 2000265-. doi:10.1002/adhm.202000265 2192-2640 https://hdl.handle.net/10356/142368 10.1002/adhm.202000265 32319223 2-s2.0-85083691282 10 9 en Advanced Healthcare Materials This is the accepted version of the following article: Guo, Z., He, J.-X., Mahadevegowda, S. H., Kho, S. H., Chan‐Park, M. B., & Liu, X.-W. (2020). Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds. Advanced Healthcare Materials, 9(10), 2000265-. doi:10.1002/adhm.202000265, which has been published in final form at https://doi.org/10.1002/adhm.202000265. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html]. application/pdf |
| spellingShingle | Science::Chemistry Active Targeting Bacteria Guo, Zhong He, Jing-Xi Mahadevegowda, Surendra Hittanahalli Kho, Shu Hui Chan-Park, Mary B. Liu, Xue-Wei Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds |
| title | Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds |
| title_full | Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds |
| title_fullStr | Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds |
| title_full_unstemmed | Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds |
| title_short | Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds |
| title_sort | multifunctional glyco nanosheets to eradicate drug resistant bacteria on wounds |
| topic | Science::Chemistry Active Targeting Bacteria |
| url | https://hdl.handle.net/10356/142368 |
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