The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics
Introduction: In tropical Singapore, influenza occurs all year‐round. This study of influenza‐confirmed hospitalized pediatric patients compared clinical characteristics and complications by age‐group and differences between influenza A and B. Methods: This was a retrospective study of pediatric inp...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/142417 |
| _version_ | 1826120434875105280 |
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| author | Chong, Chia Yin Yung, Chee Fu Gan, Cherie Thio, Szu-Tien Tan, Natalie Woon Hui Tee, Nancy Wen-Sim Lin, Cui Lin, Raymond Tze-Pin Thoon, Koh Cheng |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chong, Chia Yin Yung, Chee Fu Gan, Cherie Thio, Szu-Tien Tan, Natalie Woon Hui Tee, Nancy Wen-Sim Lin, Cui Lin, Raymond Tze-Pin Thoon, Koh Cheng |
| author_sort | Chong, Chia Yin |
| collection | NTU |
| description | Introduction: In tropical Singapore, influenza occurs all year‐round. This study of influenza‐confirmed hospitalized pediatric patients compared clinical characteristics and complications by age‐group and differences between influenza A and B. Methods: This was a retrospective study of pediatric inpatients from January 2013 to December 2014. Patients were grouped into: <6 months, 6 months to <5 years, 5‐ to <10‐year and ≥10 years. Complications were classified into neurologic, pulmonary, and other. We also calculated the incidence of hospitalized influenza cases per 100 000 age‐related population. Results: There were a total of 1272 patients with a median age of 37 months. The highest hospitalization rates were in the <6 months age‐group. Majority (75.2%) had no comorbidity; 25.6% had complications: neurologic 11.9%, pulmonary 9.6%, other 4.1%. Patients with other complications were older, male, and had the highest influenza B rates and the longest length of stay. Influenza A comprised 76.9% of cases and had higher complication rates especially neurologic, compared to influenza B. Influenza B patients were older and were more likely to develop other complications. The 6‐month to <5‐year‐age‐group had the highest complication rate (30.6%), especially neurologic. However, ≥10 years old had the highest other complications, ICU/ high‐dependency admissions and influenza B Victoria rates. Conclusions: Infants <6 months had the highest hospitalization rates for influenza. The 6‐month to <5‐year‐age‐group had the highest complication rate especially neurologic. Influenza A patients were younger, had higher seizure rates and complications compared to influenza B. |
| first_indexed | 2024-10-01T05:16:24Z |
| format | Journal Article |
| id | ntu-10356/142417 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:16:24Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1424172020-11-01T05:20:28Z The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics Chong, Chia Yin Yung, Chee Fu Gan, Cherie Thio, Szu-Tien Tan, Natalie Woon Hui Tee, Nancy Wen-Sim Lin, Cui Lin, Raymond Tze-Pin Thoon, Koh Cheng Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Complications Disease Burden Introduction: In tropical Singapore, influenza occurs all year‐round. This study of influenza‐confirmed hospitalized pediatric patients compared clinical characteristics and complications by age‐group and differences between influenza A and B. Methods: This was a retrospective study of pediatric inpatients from January 2013 to December 2014. Patients were grouped into: <6 months, 6 months to <5 years, 5‐ to <10‐year and ≥10 years. Complications were classified into neurologic, pulmonary, and other. We also calculated the incidence of hospitalized influenza cases per 100 000 age‐related population. Results: There were a total of 1272 patients with a median age of 37 months. The highest hospitalization rates were in the <6 months age‐group. Majority (75.2%) had no comorbidity; 25.6% had complications: neurologic 11.9%, pulmonary 9.6%, other 4.1%. Patients with other complications were older, male, and had the highest influenza B rates and the longest length of stay. Influenza A comprised 76.9% of cases and had higher complication rates especially neurologic, compared to influenza B. Influenza B patients were older and were more likely to develop other complications. The 6‐month to <5‐year‐age‐group had the highest complication rate (30.6%), especially neurologic. However, ≥10 years old had the highest other complications, ICU/ high‐dependency admissions and influenza B Victoria rates. Conclusions: Infants <6 months had the highest hospitalization rates for influenza. The 6‐month to <5‐year‐age‐group had the highest complication rate especially neurologic. Influenza A patients were younger, had higher seizure rates and complications compared to influenza B. Published version 2020-06-22T03:16:24Z 2020-06-22T03:16:24Z 2019 Journal Article Chong, C. Y., Yung, C. F., Gan, C., Thio, S.-T., Tan, N. W. H., Tee, N. W.-S., . . . Thoon, K. C. (2020). The burden and clinical manifestation of hospitalized influenza among different pediatric age‐groups in the tropics. Influenza and Other Respiratory Viruses, 14(1), 46-54. doi:10.1111/irv.12692 1750-2640 https://hdl.handle.net/10356/142417 10.1111/irv.12692 31608598 2-s2.0-85074025410 1 14 46 54 en Influenza and Other Respiratory Viruses © 2019 The Authors (published by John Wiley & Sons Ltd). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited application/pdf |
| spellingShingle | Science::Medicine Complications Disease Burden Chong, Chia Yin Yung, Chee Fu Gan, Cherie Thio, Szu-Tien Tan, Natalie Woon Hui Tee, Nancy Wen-Sim Lin, Cui Lin, Raymond Tze-Pin Thoon, Koh Cheng The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics |
| title | The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics |
| title_full | The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics |
| title_fullStr | The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics |
| title_full_unstemmed | The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics |
| title_short | The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics |
| title_sort | burden and clinical manifestation of hospitalized influenza among different pediatric age groups in the tropics |
| topic | Science::Medicine Complications Disease Burden |
| url | https://hdl.handle.net/10356/142417 |
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