The mutator phenotype : adapting microbial evolution to cancer biology
The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by inc...
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/142479 |
| _version_ | 1811689147855798272 |
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| author | Natali, Federica Rancati, Giulia |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Natali, Federica Rancati, Giulia |
| author_sort | Natali, Federica |
| collection | NTU |
| description | The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by increased genome instability. Given the evolutionary conservation throughout the tree of life and the genetic tractability of model organisms, yeast and bacterial species pioneered studies to dissect the functions of genes required for genome maintenance (caretaker genes) or for cell growth control (gatekeeper genes). In this review, we first provide an overview of what we learned from model organisms about the roles of these genes and the genome instability that arises as a consequence of their dysregulation. We then discuss our current understanding of how mutator phenotypes shape the evolution of bacteria and yeast species. We end by bringing clinical evidence that lessons learned from single-cell organisms can be applied to tumor evolution. |
| first_indexed | 2024-10-01T05:43:29Z |
| format | Journal Article |
| id | ntu-10356/142479 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:43:29Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1424792023-02-28T17:07:34Z The mutator phenotype : adapting microbial evolution to cancer biology Natali, Federica Rancati, Giulia School of Biological Sciences Institute of Medical Biology, A*STAR Science::Biological sciences Mutator Phenotype Cell-to-cell Heterogeneity The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by increased genome instability. Given the evolutionary conservation throughout the tree of life and the genetic tractability of model organisms, yeast and bacterial species pioneered studies to dissect the functions of genes required for genome maintenance (caretaker genes) or for cell growth control (gatekeeper genes). In this review, we first provide an overview of what we learned from model organisms about the roles of these genes and the genome instability that arises as a consequence of their dysregulation. We then discuss our current understanding of how mutator phenotypes shape the evolution of bacteria and yeast species. We end by bringing clinical evidence that lessons learned from single-cell organisms can be applied to tumor evolution. NRF (Natl Research Foundation, S’pore) Published version 2020-06-22T09:33:26Z 2020-06-22T09:33:26Z 2019 Journal Article Natali, F., & Rancati, G. (2019). The mutator phenotype : adapting microbial evolution to cancer biology. Frontiers in Genetics, 10, 713-. doi:10.3389/fgene.2019.00713 1664-3224 https://hdl.handle.net/10356/142479 10.3389/fgene.2019.00713 31447882 2-s2.0-85070553755 10 en Frontiers in Genetics © 2019 Natali and Rancati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Biological sciences Mutator Phenotype Cell-to-cell Heterogeneity Natali, Federica Rancati, Giulia The mutator phenotype : adapting microbial evolution to cancer biology |
| title | The mutator phenotype : adapting microbial evolution to cancer biology |
| title_full | The mutator phenotype : adapting microbial evolution to cancer biology |
| title_fullStr | The mutator phenotype : adapting microbial evolution to cancer biology |
| title_full_unstemmed | The mutator phenotype : adapting microbial evolution to cancer biology |
| title_short | The mutator phenotype : adapting microbial evolution to cancer biology |
| title_sort | mutator phenotype adapting microbial evolution to cancer biology |
| topic | Science::Biological sciences Mutator Phenotype Cell-to-cell Heterogeneity |
| url | https://hdl.handle.net/10356/142479 |
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