Effect of solvent composition of electrospun PLGA fibers on paclitaxel release
Site-directed delivery of antimicrobial agents for inflammatory diseases showed significant medical advances, which can be realized through drug-loaded electrospun fibers. In this study, paclitaxel was applied as model hydrophobic drug, and the effect of solvent ratio on drug distribution and releas...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/142558 |
| _version_ | 1811693001823485952 |
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| author | Chen, Huizhi Lui, Yuan Siang Zhao, Jianghui Xu, Lan Tan, Lay Poh |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Chen, Huizhi Lui, Yuan Siang Zhao, Jianghui Xu, Lan Tan, Lay Poh |
| author_sort | Chen, Huizhi |
| collection | NTU |
| description | Site-directed delivery of antimicrobial agents for inflammatory diseases showed significant medical advances, which can be realized through drug-loaded electrospun fibers. In this study, paclitaxel was applied as model hydrophobic drug, and the effect of solvent ratio on drug distribution and release kinetics would be discussed. It was found that different co-solvent ratios (9:1, 7:3, and 5:5, v:v) of chloroform and dimethylformamide could alter the resultant fiber diameter and morphology as well as paclitaxel release kinetics. Slower release was observed with higher ratio of chloroform. XPS results showed that this is primarily due to a better dispersion of paclitaxel in the fibers prepared from solvent ratio of 9:1 whereas the drug was found to accumulate on the surface for samples 5:5 and 7:3. Our results provided insight into the importance of solvent and solvent ratio not just in fabrication of required fibrous structure but also on release of active compounds. |
| first_indexed | 2024-10-01T06:44:45Z |
| format | Journal Article |
| id | ntu-10356/142558 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:44:45Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1425582020-06-24T05:48:05Z Effect of solvent composition of electrospun PLGA fibers on paclitaxel release Chen, Huizhi Lui, Yuan Siang Zhao, Jianghui Xu, Lan Tan, Lay Poh School of Materials Science and Engineering Engineering::Materials Electrospinning Fiber Site-directed delivery of antimicrobial agents for inflammatory diseases showed significant medical advances, which can be realized through drug-loaded electrospun fibers. In this study, paclitaxel was applied as model hydrophobic drug, and the effect of solvent ratio on drug distribution and release kinetics would be discussed. It was found that different co-solvent ratios (9:1, 7:3, and 5:5, v:v) of chloroform and dimethylformamide could alter the resultant fiber diameter and morphology as well as paclitaxel release kinetics. Slower release was observed with higher ratio of chloroform. XPS results showed that this is primarily due to a better dispersion of paclitaxel in the fibers prepared from solvent ratio of 9:1 whereas the drug was found to accumulate on the surface for samples 5:5 and 7:3. Our results provided insight into the importance of solvent and solvent ratio not just in fabrication of required fibrous structure but also on release of active compounds. MOE (Min. of Education, S’pore) 2020-06-24T05:48:05Z 2020-06-24T05:48:05Z 2018 Journal Article Chen, H., Lui, Y. S., Zhao, J., Xu, L., & Tan, L. P. (2018). Effect of solvent composition of electrospun PLGA fibers on paclitaxel release. Materials Technology, 33(11), 716-722. doi:10.1080/10667857.2018.1499271 1066-7857 https://hdl.handle.net/10356/142558 10.1080/10667857.2018.1499271 2-s2.0-85051713017 11 33 716 722 en Materials Technology © 2018 Informa UK Limited, trading as Taylor & Francis Group. All rights reserved. |
| spellingShingle | Engineering::Materials Electrospinning Fiber Chen, Huizhi Lui, Yuan Siang Zhao, Jianghui Xu, Lan Tan, Lay Poh Effect of solvent composition of electrospun PLGA fibers on paclitaxel release |
| title | Effect of solvent composition of electrospun PLGA fibers on paclitaxel release |
| title_full | Effect of solvent composition of electrospun PLGA fibers on paclitaxel release |
| title_fullStr | Effect of solvent composition of electrospun PLGA fibers on paclitaxel release |
| title_full_unstemmed | Effect of solvent composition of electrospun PLGA fibers on paclitaxel release |
| title_short | Effect of solvent composition of electrospun PLGA fibers on paclitaxel release |
| title_sort | effect of solvent composition of electrospun plga fibers on paclitaxel release |
| topic | Engineering::Materials Electrospinning Fiber |
| url | https://hdl.handle.net/10356/142558 |
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