Lipid profiles in Lyme borreliosis : a potential role for apheresis?
Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/142727 |
| _version_ | 1826114703474032640 |
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| author | Straube, Richard Voit-Bak, Karin Gor, A. Steinmeier, Til Chrousos, George P. Boehm, Bernhard Otto Birkenfeld, Andreas L. Barbir, Mahmoud Balanzew, Wladimir Bornstein, Stefan R. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Straube, Richard Voit-Bak, Karin Gor, A. Steinmeier, Til Chrousos, George P. Boehm, Bernhard Otto Birkenfeld, Andreas L. Barbir, Mahmoud Balanzew, Wladimir Bornstein, Stefan R. |
| author_sort | Straube, Richard |
| collection | NTU |
| description | Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In this analysis we assessed the clinical and lipid profiles of 519 patients (319 women, 200 men) with a proven history of Lyme disease, before and after an extracorporeal double membrane filtration. Lipid profiles pre- and post-apheresis were analyzed in conjunction with clinical symptoms and parameters of inflammation. Circulating cholesterol, triglycerides, LDL, LP(a), and other inflammatory lipids were significantly reduced after the apheresis, while symptoms of the disorder and bioindexes of inflammation such as CRP improved. Further studies should be initiated to investigate the possibly causal relation between Lyme disease and circulating lipids and to design appropriate therapeutic strategies. |
| first_indexed | 2024-10-01T03:43:49Z |
| format | Journal Article |
| id | ntu-10356/142727 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:43:49Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1427272020-06-29T06:43:20Z Lipid profiles in Lyme borreliosis : a potential role for apheresis? Straube, Richard Voit-Bak, Karin Gor, A. Steinmeier, Til Chrousos, George P. Boehm, Bernhard Otto Birkenfeld, Andreas L. Barbir, Mahmoud Balanzew, Wladimir Bornstein, Stefan R. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Lipidapheresis Borreliosis Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In this analysis we assessed the clinical and lipid profiles of 519 patients (319 women, 200 men) with a proven history of Lyme disease, before and after an extracorporeal double membrane filtration. Lipid profiles pre- and post-apheresis were analyzed in conjunction with clinical symptoms and parameters of inflammation. Circulating cholesterol, triglycerides, LDL, LP(a), and other inflammatory lipids were significantly reduced after the apheresis, while symptoms of the disorder and bioindexes of inflammation such as CRP improved. Further studies should be initiated to investigate the possibly causal relation between Lyme disease and circulating lipids and to design appropriate therapeutic strategies. 2020-06-29T06:43:19Z 2020-06-29T06:43:19Z 2019 Journal Article Straube, R., Voit-Bak, K., Gor, A., Steinmeier, T., Chrousos, G. P., Boehm, B. O., . . . Bornstein, S. R. (2019). Lipid profiles in Lyme borreliosis : a potential role for apheresis? Hormone and Metabolic Research, 51(5), 326-329. doi:10.1055/a-0885-7169 0018-5043 https://hdl.handle.net/10356/142727 10.1055/a-0885-7169 31071737 2-s2.0-85065622979 5 51 326 329 en Hormone and Metabolic Research © 2019 Georg Thieme Verlag KG. All rights reserved. |
| spellingShingle | Science::Medicine Lipidapheresis Borreliosis Straube, Richard Voit-Bak, Karin Gor, A. Steinmeier, Til Chrousos, George P. Boehm, Bernhard Otto Birkenfeld, Andreas L. Barbir, Mahmoud Balanzew, Wladimir Bornstein, Stefan R. Lipid profiles in Lyme borreliosis : a potential role for apheresis? |
| title | Lipid profiles in Lyme borreliosis : a potential role for apheresis? |
| title_full | Lipid profiles in Lyme borreliosis : a potential role for apheresis? |
| title_fullStr | Lipid profiles in Lyme borreliosis : a potential role for apheresis? |
| title_full_unstemmed | Lipid profiles in Lyme borreliosis : a potential role for apheresis? |
| title_short | Lipid profiles in Lyme borreliosis : a potential role for apheresis? |
| title_sort | lipid profiles in lyme borreliosis a potential role for apheresis |
| topic | Science::Medicine Lipidapheresis Borreliosis |
| url | https://hdl.handle.net/10356/142727 |
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