Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging
Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is as...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/142979 |
| _version_ | 1811689964116639744 |
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| author | Tan, Chin Hong Low, Kathy A. Chiarelli, Antonio M. Fletcher, Mark A. Navarra, Riccardo Burzynska, Agnieszka Z. Kong, Tania S. Zimmerman, Benjamin Maclin, Edward L. Sutton, Bradley P. Gratton, Gabriele Fabiani, Monica |
| author2 | School of Social Sciences |
| author_facet | School of Social Sciences Tan, Chin Hong Low, Kathy A. Chiarelli, Antonio M. Fletcher, Mark A. Navarra, Riccardo Burzynska, Agnieszka Z. Kong, Tania S. Zimmerman, Benjamin Maclin, Edward L. Sutton, Bradley P. Gratton, Gabriele Fabiani, Monica |
| author_sort | Tan, Chin Hong |
| collection | NTU |
| description | Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18-87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline. |
| first_indexed | 2024-10-01T05:56:28Z |
| format | Journal Article |
| id | ntu-10356/142979 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:56:28Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1429792020-07-17T04:58:50Z Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging Tan, Chin Hong Low, Kathy A. Chiarelli, Antonio M. Fletcher, Mark A. Navarra, Riccardo Burzynska, Agnieszka Z. Kong, Tania S. Zimmerman, Benjamin Maclin, Edward L. Sutton, Bradley P. Gratton, Gabriele Fabiani, Monica School of Social Sciences Social sciences::Psychology Aging Fluid Abilities Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18-87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline. Accepted version 2020-07-17T02:21:55Z 2020-07-17T02:21:55Z 2019 Journal Article Tan, C. H., Low, K. A., Chiarelli, A. M., Fletcher, M. A., Navarra, R., Burzynska, A. Z., . . . Fabiani, M. (2019). Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging. Neurobiology of Aging, 84, 200-207. doi:10.1016/j.neurobiolaging.2019.08.004 0197-4580 https://hdl.handle.net/10356/142979 10.1016/j.neurobiolaging.2019.08.004 31500910 2-s2.0-85071715995 84 200 207 en Neurobiology of Aging © 2019 Elsevier Inc. All rights reserved. This paper was published in Neurobiology of Aging and is made available with permission of Elsevier Inc. application/pdf |
| spellingShingle | Social sciences::Psychology Aging Fluid Abilities Tan, Chin Hong Low, Kathy A. Chiarelli, Antonio M. Fletcher, Mark A. Navarra, Riccardo Burzynska, Agnieszka Z. Kong, Tania S. Zimmerman, Benjamin Maclin, Edward L. Sutton, Bradley P. Gratton, Gabriele Fabiani, Monica Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| title | Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| title_full | Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| title_fullStr | Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| title_full_unstemmed | Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| title_short | Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| title_sort | optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging |
| topic | Social sciences::Psychology Aging Fluid Abilities |
| url | https://hdl.handle.net/10356/142979 |
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