Synthesis and characterization of imidazolium based antimicrobial polymer
Antibiotics underpin modern medical interventions such as surgeries, chemotherapy and implants. Recent emergence of multidrug-resistant bacteria together with antibiotic overuse threatens the global public health and causes significant mortality and morbidity with its associated economic loss. Numer...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2020
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| Online Access: | https://hdl.handle.net/10356/143214 |
| _version_ | 1826111163001208832 |
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| author | Zhong, Wenbin |
| author2 | Chan Bee Eng, Mary |
| author_facet | Chan Bee Eng, Mary Zhong, Wenbin |
| author_sort | Zhong, Wenbin |
| collection | NTU |
| description | Antibiotics underpin modern medical interventions such as surgeries, chemotherapy and implants. Recent emergence of multidrug-resistant bacteria together with antibiotic overuse threatens the global public health and causes significant mortality and morbidity with its associated economic loss. Numerous efforts have been dedicated to address this issue, yet no effective and safe therapeutics had been developed to treat certain notorious bacterial strains that are the predominant culprits for the global antimicrobial resistance (AMR), specifically the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). In this thesis, we synthesized imidazolium-based antimicrobial polymers and found that certain optimised compositions have outstanding bactericidal killing properties like those of antibiotics, and those compounds have good selectivity of bacterial species over mammalian cells. We evaluate their in vitro and in vivo bactericidal and toxicity properties and attempt to elucidate their mechanisms. |
| first_indexed | 2024-10-01T02:46:09Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/143214 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:46:09Z |
| publishDate | 2020 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1432142020-10-28T08:40:31Z Synthesis and characterization of imidazolium based antimicrobial polymer Zhong, Wenbin Chan Bee Eng, Mary School of Chemical and Biomedical Engineering MBEChan@ntu.edu.sg Engineering::Materials::Biomaterials Engineering::Bioengineering Antibiotics underpin modern medical interventions such as surgeries, chemotherapy and implants. Recent emergence of multidrug-resistant bacteria together with antibiotic overuse threatens the global public health and causes significant mortality and morbidity with its associated economic loss. Numerous efforts have been dedicated to address this issue, yet no effective and safe therapeutics had been developed to treat certain notorious bacterial strains that are the predominant culprits for the global antimicrobial resistance (AMR), specifically the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). In this thesis, we synthesized imidazolium-based antimicrobial polymers and found that certain optimised compositions have outstanding bactericidal killing properties like those of antibiotics, and those compounds have good selectivity of bacterial species over mammalian cells. We evaluate their in vitro and in vivo bactericidal and toxicity properties and attempt to elucidate their mechanisms. Doctor of Philosophy 2020-08-13T00:27:46Z 2020-08-13T00:27:46Z 2019 Thesis-Doctor of Philosophy Zhong, W. (2019). Synthesis and characterization of imidazolium based antimicrobial polymer. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/143214 10.32657/10356/143214 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Materials::Biomaterials Engineering::Bioengineering Zhong, Wenbin Synthesis and characterization of imidazolium based antimicrobial polymer |
| title | Synthesis and characterization of imidazolium based antimicrobial polymer |
| title_full | Synthesis and characterization of imidazolium based antimicrobial polymer |
| title_fullStr | Synthesis and characterization of imidazolium based antimicrobial polymer |
| title_full_unstemmed | Synthesis and characterization of imidazolium based antimicrobial polymer |
| title_short | Synthesis and characterization of imidazolium based antimicrobial polymer |
| title_sort | synthesis and characterization of imidazolium based antimicrobial polymer |
| topic | Engineering::Materials::Biomaterials Engineering::Bioengineering |
| url | https://hdl.handle.net/10356/143214 |
| work_keys_str_mv | AT zhongwenbin synthesisandcharacterizationofimidazoliumbasedantimicrobialpolymer |