Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases
Neurological disorders are found to be influencing the peripheral tissues outside CNS. Recent developments in biomarkers for CNS have emerged with various diagnostic and therapeutic shortcomings. The role of central biomarkers including CSF-based and molecular imaging-based probes are still unclear...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/143495 |
| _version_ | 1826114880792428544 |
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| author | Htike, Thein Than Mishra, Sachin Kumar, Sundramurthy Padmanabhan, Parasuraman Gulyás, Balázs |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Htike, Thein Than Mishra, Sachin Kumar, Sundramurthy Padmanabhan, Parasuraman Gulyás, Balázs |
| author_sort | Htike, Thein Than |
| collection | NTU |
| description | Neurological disorders are found to be influencing the peripheral tissues outside CNS. Recent developments in biomarkers for CNS have emerged with various diagnostic and therapeutic shortcomings. The role of central biomarkers including CSF-based and molecular imaging-based probes are still unclear for early diagnosis of major neurological diseases. Current trends show that early detection of neurodegenerative diseases with non-invasive methods is a major focus of researchers, and the development of biomarkers aiming peripheral tissues is in demand. Alzheimer's and Parkinson's diseases are known for the progressive loss in neural structures or functions, including the neural death. Various dysfunctions of metabolic and biochemical pathways are associated with early occurrence of neuro-disorders in peripheral tissues including skin, blood cells, and eyes. This article reviews the peripheral biomarkers explored for early detection of Alzheimer's and Parkinson's diseases including blood cells, skin fibroblast, proteomics, saliva, olfactory, stomach and colon, heart and peripheral nervous system, and others. |
| first_indexed | 2024-10-01T03:46:26Z |
| format | Journal Article |
| id | ntu-10356/143495 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:46:26Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1434952020-11-01T05:15:22Z Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases Htike, Thein Than Mishra, Sachin Kumar, Sundramurthy Padmanabhan, Parasuraman Gulyás, Balázs Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Peripheral Biomarkers Alzheimer’s Disease Neurological disorders are found to be influencing the peripheral tissues outside CNS. Recent developments in biomarkers for CNS have emerged with various diagnostic and therapeutic shortcomings. The role of central biomarkers including CSF-based and molecular imaging-based probes are still unclear for early diagnosis of major neurological diseases. Current trends show that early detection of neurodegenerative diseases with non-invasive methods is a major focus of researchers, and the development of biomarkers aiming peripheral tissues is in demand. Alzheimer's and Parkinson's diseases are known for the progressive loss in neural structures or functions, including the neural death. Various dysfunctions of metabolic and biochemical pathways are associated with early occurrence of neuro-disorders in peripheral tissues including skin, blood cells, and eyes. This article reviews the peripheral biomarkers explored for early detection of Alzheimer's and Parkinson's diseases including blood cells, skin fibroblast, proteomics, saliva, olfactory, stomach and colon, heart and peripheral nervous system, and others. Ministry of Education (MOE) Nanyang Technological University Accepted version The authors (BG and PP) acknowledges The Lee Kong Chian School of Medicine, Nanyang Technological University MOE Start-Up Grant and MOE Tier-1 grants (2014-T1-001-229-1T1-04/14 and L0421160-1T1-06/15), Singapore. 2020-09-04T07:36:12Z 2020-09-04T07:36:12Z 2018 Journal Article Htike, T. T., Mishra, S., Kumar, S., Padmanabhan, P., & Gulyás, B. (2019). Peripheral biomarkers for early detection of Alzheimer’s and Parkinson’s diseases. Molecular Neurobiology, 56(3), 2256-2277. doi:10.1007/s12035-018-1151-4 0893-7648 https://hdl.handle.net/10356/143495 10.1007/s12035-018-1151-4 30008073 2-s2.0-85049896983 3 56 2256 2277 en Molecular Neurobiology © 2019 Springer Science+Business Media. This is a post-peer-review, pre-copyedit version of an article published in Molecular Neurobiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12035-018-1151-4 application/pdf |
| spellingShingle | Science::Medicine Peripheral Biomarkers Alzheimer’s Disease Htike, Thein Than Mishra, Sachin Kumar, Sundramurthy Padmanabhan, Parasuraman Gulyás, Balázs Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases |
| title | Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases |
| title_full | Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases |
| title_fullStr | Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases |
| title_full_unstemmed | Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases |
| title_short | Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases |
| title_sort | peripheral biomarkers for early detection of alzheimer s and parkinson s diseases |
| topic | Science::Medicine Peripheral Biomarkers Alzheimer’s Disease |
| url | https://hdl.handle.net/10356/143495 |
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