Biomimicking fiber platform with tunable stiffness to study mechanotransduction reveals stiffness enhances oligodendrocyte differentiation but impedes myelination through YAP-dependent regulation

Biomimicking fiber platform with tunable stiffness to study mechanotransduction reveals stiffness enhances oligodendrocyte differentiation but impedes myelination through YAP-dependent regulation

A key hallmark of many diseases, especially those in the central nervous system (CNS), is the change in tissue stiffness due to inflammation and scarring. However, how such changes in microenvironment affect the regenerative process remains poorly understood. Here, we report a biomimicking fiber pla...

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Bibliographic Details
Main Authors: Ong, William, Marinval, Nicolas, Lin, Junquan, Nai, Mui Hoon, Chong, Yee-Song, Pinese, Coline, Sajikumar, Sreedharan, Lim, Chwee Teck, Ffrench-Constant, Charles, Bechler, Marie E., Chew, Sing Yian
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2020
Subjects:
Engineering::Chemical engineering
Biomaterials
Myelination
Online Access:https://hdl.handle.net/10356/143758

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