Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound
The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/144011 |
| _version_ | 1811676792101011456 |
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| author | Shadi Sedghi Masoud Yamaoki, Yudai Ma, Yue Marchand, Adrien Winnerdy, Fernaldo Richtia Gabelica, Valérie Phan, Anh Tuân Katahira, Masato Nagasawa, Kazuo |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Shadi Sedghi Masoud Yamaoki, Yudai Ma, Yue Marchand, Adrien Winnerdy, Fernaldo Richtia Gabelica, Valérie Phan, Anh Tuân Katahira, Masato Nagasawa, Kazuo |
| author_sort | Shadi Sedghi Masoud |
| collection | NTU |
| description | The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites. |
| first_indexed | 2024-10-01T02:27:06Z |
| format | Journal Article |
| id | ntu-10356/144011 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:27:06Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1440112022-03-11T02:34:02Z Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound Shadi Sedghi Masoud Yamaoki, Yudai Ma, Yue Marchand, Adrien Winnerdy, Fernaldo Richtia Gabelica, Valérie Phan, Anh Tuân Katahira, Masato Nagasawa, Kazuo School of Physical and Mathematical Sciences Engineering::Chemical engineering::Biotechnology DNA G-quadruplexes The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites. 2020-10-08T02:14:38Z 2020-10-08T02:14:38Z 2018 Journal Article Shadi Sedghi Masoud, Yamaoki, Y., Ma, Y., Marchand, A., Winnerdy, F. R., Gabelica, V., ... Nagasawa, K. (2018). Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound. ChemBioChem, 19(21), 2268-2272. doi:10.1002/cbic.201800425 1439-4227 https://hdl.handle.net/10356/144011 10.1002/cbic.201800425 30160816 21 19 2268 2272 en ChemBioChem © 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering::Biotechnology DNA G-quadruplexes Shadi Sedghi Masoud Yamaoki, Yudai Ma, Yue Marchand, Adrien Winnerdy, Fernaldo Richtia Gabelica, Valérie Phan, Anh Tuân Katahira, Masato Nagasawa, Kazuo Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound |
| title | Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound |
| title_full | Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound |
| title_fullStr | Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound |
| title_full_unstemmed | Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound |
| title_short | Analysis of interactions between telomeric i-motif DNA and a cyclic tetraoxazole compound |
| title_sort | analysis of interactions between telomeric i motif dna and a cyclic tetraoxazole compound |
| topic | Engineering::Chemical engineering::Biotechnology DNA G-quadruplexes |
| url | https://hdl.handle.net/10356/144011 |
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