Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation
Microbial biofilms are the cause of persistent infections associated with various medical implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with their free living counterparts, bacteria in biofilms display a highly increased resistance to immune system activitie...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/144050 |
| _version_ | 1811696542648631296 |
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| author | Qvortrup, Katrine Hultqvist, Louise Dahl Nilsson, Martin Jakobsen, Tim Holm Jansen, Charlotte Uldahl Uhd, Jesper Andersen, Jens Bo Nielsen, Thomas Eiland Givskov, Michael Tolker-Nielsen, Tim |
| author2 | Singapore Centre for Environmental Life Sciences and Engineering |
| author_facet | Singapore Centre for Environmental Life Sciences and Engineering Qvortrup, Katrine Hultqvist, Louise Dahl Nilsson, Martin Jakobsen, Tim Holm Jansen, Charlotte Uldahl Uhd, Jesper Andersen, Jens Bo Nielsen, Thomas Eiland Givskov, Michael Tolker-Nielsen, Tim |
| author_sort | Qvortrup, Katrine |
| collection | NTU |
| description | Microbial biofilms are the cause of persistent infections associated with various medical implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with their free living counterparts, bacteria in biofilms display a highly increased resistance to immune system activities and antibiotic treatment. Therefore, biofilm infections are difficult or impossible to treat with our current armory of antibiotics. The challenges associated with biofilm infections have urged researchers to pursue a better understanding of the molecular mechanisms that are involved in the formation and dispersal of biofilms, and this has led to the identification of several steps that could be targeted in order to eradicate these challenging infections. Here we describe mechanisms that are involved in the regulation of biofilm development in Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii, and provide examples of chemical compounds that have been developed to specifically inhibit these processes. These compounds include (i) pilicides and curlicides which inhibit the initial steps of biofilm formation by E. coli; (ii) compounds that interfere with c-di-GMP signaling in P. aeruginosa and E. coli; and (iii) compounds that inhibit quorum-sensing in P. aeruginosa and A. baumannii. In cases where compound series have a defined molecular target, we focus on elucidating structure activity relationship (SAR) trends within the particular compound series. |
| first_indexed | 2024-10-01T07:41:01Z |
| format | Journal Article |
| id | ntu-10356/144050 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:41:01Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1440502020-10-10T20:11:30Z Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation Qvortrup, Katrine Hultqvist, Louise Dahl Nilsson, Martin Jakobsen, Tim Holm Jansen, Charlotte Uldahl Uhd, Jesper Andersen, Jens Bo Nielsen, Thomas Eiland Givskov, Michael Tolker-Nielsen, Tim Singapore Centre for Environmental Life Sciences and Engineering Science::General Pseudomonas Aeruginosa Escherichia Coli Microbial biofilms are the cause of persistent infections associated with various medical implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with their free living counterparts, bacteria in biofilms display a highly increased resistance to immune system activities and antibiotic treatment. Therefore, biofilm infections are difficult or impossible to treat with our current armory of antibiotics. The challenges associated with biofilm infections have urged researchers to pursue a better understanding of the molecular mechanisms that are involved in the formation and dispersal of biofilms, and this has led to the identification of several steps that could be targeted in order to eradicate these challenging infections. Here we describe mechanisms that are involved in the regulation of biofilm development in Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii, and provide examples of chemical compounds that have been developed to specifically inhibit these processes. These compounds include (i) pilicides and curlicides which inhibit the initial steps of biofilm formation by E. coli; (ii) compounds that interfere with c-di-GMP signaling in P. aeruginosa and E. coli; and (iii) compounds that inhibit quorum-sensing in P. aeruginosa and A. baumannii. In cases where compound series have a defined molecular target, we focus on elucidating structure activity relationship (SAR) trends within the particular compound series. Published version 2020-10-09T08:47:25Z 2020-10-09T08:47:25Z 2019 Journal Article Qvortrup, K., Hultqvist, L. D., Nilsson, M., Jakobsen, T. H., Jansen, C. U., Uhd, J., ... Tolker-Nielsen, T. (2019). Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation. Frontiers in Chemistry, 7, 742-. doi:10.3389/fchem.2019.00742 2296-2646 https://hdl.handle.net/10356/144050 10.3389/fchem.2019.00742 31737611 7 en Frontiers in Chemistry © 2019 Qvortrup, Hultqvist, Nilsson, Jakobsen, Jansen, Uhd, Andersen, Nielsen, Givskov and Tolker-Nielsen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::General Pseudomonas Aeruginosa Escherichia Coli Qvortrup, Katrine Hultqvist, Louise Dahl Nilsson, Martin Jakobsen, Tim Holm Jansen, Charlotte Uldahl Uhd, Jesper Andersen, Jens Bo Nielsen, Thomas Eiland Givskov, Michael Tolker-Nielsen, Tim Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| title | Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| title_full | Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| title_fullStr | Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| title_full_unstemmed | Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| title_short | Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| title_sort | small molecule anti biofilm agents developed on the basis of mechanistic understanding of biofilm formation |
| topic | Science::General Pseudomonas Aeruginosa Escherichia Coli |
| url | https://hdl.handle.net/10356/144050 |
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