Functional analysis of clinical BARD1 germline variants

Functional analysis of clinical BARD1 germline variants

Germline pathogenic variants in BRCA1/2 account for one-third of familial breast cancers. The majority of BRCA1 function requires heterodimerization with BARD1. In contrast to BRCA1, BARD1 is a low-penetrance gene with an unclear clinical relevance, partly because of limited functional evidence. Usi...

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Bibliographic Details
Main Authors: Toh, Ming Ren, Chong, Siao Ting, Chan, Sock Hoai, Low, Chen Ee, Nur Diana Binte Ishak, Lim, Jing Quan, Courtney, Eliza, Ngeow, Joanne
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Germline Mutation
BARD1 Gene
Online Access:https://hdl.handle.net/10356/144179

Internet

https://hdl.handle.net/10356/144179

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