Hepatic PPARα is critical in the metabolic adaptation to sepsis
Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, wh...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/144807 |
| _version_ | 1824456224916111360 |
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| author | Paumelle, Réjane Haas, Joel T. Hennuyer, Nathalie Baugé, Eric Deleye, Yann Mesotten, Dieter Langouche, Lies Vanhoutte, Jonathan Cudejko, Céline Wouters, Kristiaan Hannou, Sarah Anissa Legry, Vanessa Lancel, Steve Lalloyer, Fanny Polizzi, Arnaud Smati, Sarra Gourdy, Pierre Vallez, Emmanuelle Bouchaert, Emmanuel Derudas, Bruno Dehondt, Hélène Gheeraert, Céline Fleury, Sébastien Tailleux, Anne Montagner, Alexandra Wahli, Walter Van Den Berghe, Greet Guillou, Hervé Dombrowicz, David Staels, Bart |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Paumelle, Réjane Haas, Joel T. Hennuyer, Nathalie Baugé, Eric Deleye, Yann Mesotten, Dieter Langouche, Lies Vanhoutte, Jonathan Cudejko, Céline Wouters, Kristiaan Hannou, Sarah Anissa Legry, Vanessa Lancel, Steve Lalloyer, Fanny Polizzi, Arnaud Smati, Sarra Gourdy, Pierre Vallez, Emmanuelle Bouchaert, Emmanuel Derudas, Bruno Dehondt, Hélène Gheeraert, Céline Fleury, Sébastien Tailleux, Anne Montagner, Alexandra Wahli, Walter Van Den Berghe, Greet Guillou, Hervé Dombrowicz, David Staels, Bart |
| author_sort | Paumelle, Réjane |
| collection | NTU |
| description | Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, which controls both lipid metabolism and inflammation. We aimed to elucidate the previously unknown role of hepatic PPARα in the response to sepsis. |
| first_indexed | 2025-02-19T03:50:43Z |
| format | Journal Article |
| id | ntu-10356/144807 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:50:43Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1448072020-11-25T02:58:38Z Hepatic PPARα is critical in the metabolic adaptation to sepsis Paumelle, Réjane Haas, Joel T. Hennuyer, Nathalie Baugé, Eric Deleye, Yann Mesotten, Dieter Langouche, Lies Vanhoutte, Jonathan Cudejko, Céline Wouters, Kristiaan Hannou, Sarah Anissa Legry, Vanessa Lancel, Steve Lalloyer, Fanny Polizzi, Arnaud Smati, Sarra Gourdy, Pierre Vallez, Emmanuelle Bouchaert, Emmanuel Derudas, Bruno Dehondt, Hélène Gheeraert, Céline Fleury, Sébastien Tailleux, Anne Montagner, Alexandra Wahli, Walter Van Den Berghe, Greet Guillou, Hervé Dombrowicz, David Staels, Bart Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Nuclear Receptors Sepsis Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, which controls both lipid metabolism and inflammation. We aimed to elucidate the previously unknown role of hepatic PPARα in the response to sepsis. 2020-11-25T02:53:20Z 2020-11-25T02:53:20Z 2019 Journal Article Paumelle, R., Haas, J. T., Hennuyer, N., Baugé, E., Deleye, Y., Mesotten, D., . . . Staels, B. (2019). Hepatic PPARα is critical in the metabolic adaptation to sepsis. Journal of Hepatology, 70(5), 963-973. doi:10.1016/j.jhep.2018.12.037 0168-8278 https://hdl.handle.net/10356/144807 10.1016/j.jhep.2018.12.037 30677458 5 70 963 973 en Journal of Hepatology © 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved |
| spellingShingle | Science::Medicine Nuclear Receptors Sepsis Paumelle, Réjane Haas, Joel T. Hennuyer, Nathalie Baugé, Eric Deleye, Yann Mesotten, Dieter Langouche, Lies Vanhoutte, Jonathan Cudejko, Céline Wouters, Kristiaan Hannou, Sarah Anissa Legry, Vanessa Lancel, Steve Lalloyer, Fanny Polizzi, Arnaud Smati, Sarra Gourdy, Pierre Vallez, Emmanuelle Bouchaert, Emmanuel Derudas, Bruno Dehondt, Hélène Gheeraert, Céline Fleury, Sébastien Tailleux, Anne Montagner, Alexandra Wahli, Walter Van Den Berghe, Greet Guillou, Hervé Dombrowicz, David Staels, Bart Hepatic PPARα is critical in the metabolic adaptation to sepsis |
| title | Hepatic PPARα is critical in the metabolic adaptation to sepsis |
| title_full | Hepatic PPARα is critical in the metabolic adaptation to sepsis |
| title_fullStr | Hepatic PPARα is critical in the metabolic adaptation to sepsis |
| title_full_unstemmed | Hepatic PPARα is critical in the metabolic adaptation to sepsis |
| title_short | Hepatic PPARα is critical in the metabolic adaptation to sepsis |
| title_sort | hepatic pparα is critical in the metabolic adaptation to sepsis |
| topic | Science::Medicine Nuclear Receptors Sepsis |
| url | https://hdl.handle.net/10356/144807 |
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