Targeted inhibition of purine metabolism is effective in suppressing hepatocellular carcinoma progression

Targeted inhibition of purine metabolism is effective in suppressing hepatocellular carcinoma progression

Tumor-specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development. Hepatocellular carcinoma (HCC), a malignancy that has hitherto been resistant to compounds targeting oncogenic signaling p...

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Bibliographic Details
Main Authors: Chong, Yong Chun, Toh, Tan Boon, Chan, Zhiling, Lin, Quy Xiao Xuan, Thng, Dexter Kai Hao, Hooi, Lissa, Ding, Zhaobing, Shuen, Timothy, Toh, Han Chong, Dan, Yock Young, Bonney, Glenn Kunnath, Zhou, Lei, Chow, Pierce, Wang, Yulan, Benoukraf, Touati, Chow, Edward Kai-Hua, Han, Weiping
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Hepatocellular Carcinoma
Tumor
Online Access:https://hdl.handle.net/10356/144809

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