SMP domain proteins in membrane lipid dynamics
Synaptotagmin-like mitochondrial-lipid-binding (SMP) domain proteins are evolutionarily conserved family of proteins in eukaryotes that localize between the endoplasmic reticulum (ER) and either the plasma membrane (PM) or other organelles. They are involved in tethering of these membrane contact si...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/144885 |
| _version_ | 1811696999825670144 |
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| author | Jeyasimman, Darshini Saheki, Yasunori |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Jeyasimman, Darshini Saheki, Yasunori |
| author_sort | Jeyasimman, Darshini |
| collection | NTU |
| description | Synaptotagmin-like mitochondrial-lipid-binding (SMP) domain proteins are evolutionarily conserved family of proteins in eukaryotes that localize between the endoplasmic reticulum (ER) and either the plasma membrane (PM) or other organelles. They are involved in tethering of these membrane contact sites through interaction with other proteins and membrane lipids. Recent structural and biochemical studies have demonstrated that SMP domain proteins transport a wide variety of lipid species by the ability of the SMP domain to harbor lipids through its unique hydrophobic cavity. Growing evidence suggests that SMP domain proteins play critical roles in cell physiology by their actions at membrane contact sites. In this review, we summarize the functions of SMP domain proteins and their direct roles in lipid transport across different membrane compartments. We also discuss their physiological functions in organisms as well as “bypass” pathways that act in parallel with SMP domain proteins at membrane contact sites. |
| first_indexed | 2024-10-01T07:48:17Z |
| format | Journal Article |
| id | ntu-10356/144885 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:48:17Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1448852023-03-05T16:46:54Z SMP domain proteins in membrane lipid dynamics Jeyasimman, Darshini Saheki, Yasunori Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine TULIP SMP Synaptotagmin-like mitochondrial-lipid-binding (SMP) domain proteins are evolutionarily conserved family of proteins in eukaryotes that localize between the endoplasmic reticulum (ER) and either the plasma membrane (PM) or other organelles. They are involved in tethering of these membrane contact sites through interaction with other proteins and membrane lipids. Recent structural and biochemical studies have demonstrated that SMP domain proteins transport a wide variety of lipid species by the ability of the SMP domain to harbor lipids through its unique hydrophobic cavity. Growing evidence suggests that SMP domain proteins play critical roles in cell physiology by their actions at membrane contact sites. In this review, we summarize the functions of SMP domain proteins and their direct roles in lipid transport across different membrane compartments. We also discuss their physiological functions in organisms as well as “bypass” pathways that act in parallel with SMP domain proteins at membrane contact sites. Ministry of Education (MOE) Accepted version We apologize to all the investigators whose work could not be cited due to space limitations. We thank Bilge Ercan for her help in the visualization of the structures of the SMP domains and Jingbo Sun, Nur Raihanah Binte Mohd Harion, Tomoki Naito, and Dylan Hong Zheng Koh for their constructive feedback to the manuscript. Work from the authors related to this review has been supported in part by a Grant-in-Aid for Young Scientists (A) from the Japan Society for the Promotion of Science (17H05065), the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2017-T2-2-001), Academic Research Fund Tier 1 (MOE2018-T1-001-023), a Nanyang Assistant Professorship (NAP), and a Lee Kong Chian School of Medicine startup grant (LKCMedicine-SUG) to Y.S. 2020-12-02T04:05:11Z 2020-12-02T04:05:11Z 2020 Journal Article Jeyasimman, D., & Saheki, Y. (2020). SMP domain proteins in membrane lipid dynamics. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1865(1), 158447-. doi:10.1016/j.bbalip.2019.04.007 1388-1981 https://hdl.handle.net/10356/144885 10.1016/j.bbalip.2019.04.007 1 1865 en Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids © 2019 Elsevier B.V. All rights reserved. This paper was published in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids and is made available with permission of Elsevier B.V. application/pdf |
| spellingShingle | Science::Medicine TULIP SMP Jeyasimman, Darshini Saheki, Yasunori SMP domain proteins in membrane lipid dynamics |
| title | SMP domain proteins in membrane lipid dynamics |
| title_full | SMP domain proteins in membrane lipid dynamics |
| title_fullStr | SMP domain proteins in membrane lipid dynamics |
| title_full_unstemmed | SMP domain proteins in membrane lipid dynamics |
| title_short | SMP domain proteins in membrane lipid dynamics |
| title_sort | smp domain proteins in membrane lipid dynamics |
| topic | Science::Medicine TULIP SMP |
| url | https://hdl.handle.net/10356/144885 |
| work_keys_str_mv | AT jeyasimmandarshini smpdomainproteinsinmembranelipiddynamics AT sahekiyasunori smpdomainproteinsinmembranelipiddynamics |