Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontaneously develop steatosis without obesity in aging. St...

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Bibliographic Details
Main Authors: Régnier, Marion, Polizzi, Arnaud, Smati, Sarra, Lukowicz, Céline, Fougerat, Anne, Lippi, Yannick, Fouché, Edwin, Lasserre, Frédéric, Naylies, Claire, Bétoulières, Colette, Barquissau, Valentin, Mouisel, Etienne, Bertrand-Michel, Justine, Batut, Aurélie, Saati, Talal Al, Canlet, Cécile, Tremblay-Franco, Marie, Ellero-Simatos, Sandrine, Langin, Dominique, Postic, Catherine, Wahli, Walter, Loiseau, Nicolas, Guillou, Hervé, Montagner, Alexandra
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Metabolic Disorders
Systems Analysis
Online Access:https://hdl.handle.net/10356/144951

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