Oxytocin in metabolic homeostasis : implications for obesity and diabetes management
Oxytocin was once understood solely as a neuropeptide with a central role in social bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence indicates that oxytocin enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle, suggesting that dysf...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/145339 |
| _version_ | 1811695454805557248 |
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| author | Ding, C. Leow, Melvin Khee-Shing Magkos, F. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Ding, C. Leow, Melvin Khee-Shing Magkos, F. |
| author_sort | Ding, C. |
| collection | NTU |
| description | Oxytocin was once understood solely as a neuropeptide with a central role in social bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence indicates that oxytocin enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle, suggesting that dysfunction of the oxytocin system could underlie the pathogenesis of insulin resistance and dyslipidaemia. Murine studies revealed that deficiencies in oxytocin signalling and oxytocin receptor expression lead to obesity despite normal food intake, motor activity and increased leptin levels. In addition, plasma oxytocin concentration is notably lower in obese individuals with diabetes, which may suggest an involvement of the oxytocin system in the pathogenesis of cardiometabolic disease. More recently, small scale studies demonstrated that intranasal administration of oxytocin was associated with significant weight loss as well as improvements in insulin sensitivity and pancreatic β-cell responsivity in human subjects. The multi-pronged effects of oxytocin signalling on improving peripheral insulin sensitivity, pancreatic function and lipid homeostasis strongly suggest a role for this system as a therapeutic target in obesity and diabetes management. The complexity of obesity aetiology and the pathogenesis of obesity-related metabolic complications underscore the need for a systems approach to better understand the role of oxytocin in metabolic function. |
| first_indexed | 2024-10-01T07:23:44Z |
| format | Journal Article |
| id | ntu-10356/145339 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:23:44Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1453392023-03-05T16:43:14Z Oxytocin in metabolic homeostasis : implications for obesity and diabetes management Ding, C. Leow, Melvin Khee-Shing Magkos, F. Lee Kong Chian School of Medicine (LKCMedicine) Singapore Institute for Clinical Sciences (SICS), A*Star Clinical Nutrition Research Centre (CNRC), A*Star Science::Medicine Beta Cell Function Glucose Metabolism Oxytocin was once understood solely as a neuropeptide with a central role in social bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence indicates that oxytocin enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle, suggesting that dysfunction of the oxytocin system could underlie the pathogenesis of insulin resistance and dyslipidaemia. Murine studies revealed that deficiencies in oxytocin signalling and oxytocin receptor expression lead to obesity despite normal food intake, motor activity and increased leptin levels. In addition, plasma oxytocin concentration is notably lower in obese individuals with diabetes, which may suggest an involvement of the oxytocin system in the pathogenesis of cardiometabolic disease. More recently, small scale studies demonstrated that intranasal administration of oxytocin was associated with significant weight loss as well as improvements in insulin sensitivity and pancreatic β-cell responsivity in human subjects. The multi-pronged effects of oxytocin signalling on improving peripheral insulin sensitivity, pancreatic function and lipid homeostasis strongly suggest a role for this system as a therapeutic target in obesity and diabetes management. The complexity of obesity aetiology and the pathogenesis of obesity-related metabolic complications underscore the need for a systems approach to better understand the role of oxytocin in metabolic function. Agency for Science, Technology and Research (A*STAR) Published version This review was supported by award BMSI/16-07803C-R20H from the Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore. 2020-12-17T07:47:04Z 2020-12-17T07:47:04Z 2019 Journal Article Ding, C., Leow, M. K. ‐. S., & Magkos, F. (2018). Oxytocin in metabolic homeostasis : implications for obesity and diabetes management. Obesity Reviews, 20(1), 22–40. doi:10.1111/obr.12757 1467-7881 https://hdl.handle.net/10356/145339 10.1111/obr.12757 30253045 1 20 22 40 en Obesity reviews © 2018 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. application/pdf |
| spellingShingle | Science::Medicine Beta Cell Function Glucose Metabolism Ding, C. Leow, Melvin Khee-Shing Magkos, F. Oxytocin in metabolic homeostasis : implications for obesity and diabetes management |
| title | Oxytocin in metabolic homeostasis : implications for obesity and diabetes management |
| title_full | Oxytocin in metabolic homeostasis : implications for obesity and diabetes management |
| title_fullStr | Oxytocin in metabolic homeostasis : implications for obesity and diabetes management |
| title_full_unstemmed | Oxytocin in metabolic homeostasis : implications for obesity and diabetes management |
| title_short | Oxytocin in metabolic homeostasis : implications for obesity and diabetes management |
| title_sort | oxytocin in metabolic homeostasis implications for obesity and diabetes management |
| topic | Science::Medicine Beta Cell Function Glucose Metabolism |
| url | https://hdl.handle.net/10356/145339 |
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