First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity
Intragastric balloons (IGBs) are an established treatment option for obesity. Major barriers to dissemination of IGBs include lack of long-term efficacy outcomes, safety concerns, cost, and tolerability. We developed a novel ingestible magnetically inflated balloon capsule (IMI-BC) in hopes of overc...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/145348 |
| _version_ | 1826119368091631616 |
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| author | Kaan, Hung Leng Phan, Phuoc Thien Tiong, Anthony Meng Huat Miyasaka, Muneaki Phee, Soo Jay Ho, Khek Yu |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Kaan, Hung Leng Phan, Phuoc Thien Tiong, Anthony Meng Huat Miyasaka, Muneaki Phee, Soo Jay Ho, Khek Yu |
| author_sort | Kaan, Hung Leng |
| collection | NTU |
| description | Intragastric balloons (IGBs) are an established treatment option for obesity. Major barriers to dissemination of IGBs include lack of long-term efficacy outcomes, safety concerns, cost, and tolerability. We developed a novel ingestible magnetically inflated balloon capsule (IMI-BC) in hopes of overcoming these challenges. The IMI-BC is significantly cheaper than IGBs currently available on the market. We performed proof-of-concept animal studies and a first-in-human feasibility study to demonstrate the feasibility of inflating the IMI-BC using an external magnet. Further studies are currently being conducted to evaluate the safety, tolerability, and long-term efficacy of the IMI-BC. When fully developed, we anticipate that this device will benefit obese patients. |
| first_indexed | 2024-10-01T04:58:49Z |
| format | Journal Article |
| id | ntu-10356/145348 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:58:49Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1453482020-12-18T01:43:19Z First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity Kaan, Hung Leng Phan, Phuoc Thien Tiong, Anthony Meng Huat Miyasaka, Muneaki Phee, Soo Jay Ho, Khek Yu School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering Intragastric Balloons Obesity Intragastric balloons (IGBs) are an established treatment option for obesity. Major barriers to dissemination of IGBs include lack of long-term efficacy outcomes, safety concerns, cost, and tolerability. We developed a novel ingestible magnetically inflated balloon capsule (IMI-BC) in hopes of overcoming these challenges. The IMI-BC is significantly cheaper than IGBs currently available on the market. We performed proof-of-concept animal studies and a first-in-human feasibility study to demonstrate the feasibility of inflating the IMI-BC using an external magnet. Further studies are currently being conducted to evaluate the safety, tolerability, and long-term efficacy of the IMI-BC. When fully developed, we anticipate that this device will benefit obese patients. Published version 2020-12-18T01:43:19Z 2020-12-18T01:43:19Z 2020 Journal Article Kaan, H. L., Phan, P. T., Tiong, A. M. H., Miyasaka, M., Phee, S. J., & Ho, K. Y. (2020). First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity. Endoscopy International Open, 8(5), E607-E610. doi:10.1055/a-1127-2991 2364-3722 https://hdl.handle.net/10356/145348 10.1055/a-1127-2991 32355877 5 8 E607 E610 en Endoscopy International Open © 2020 The Author(s) (published by Georg Thieme Verlag KG Stuttgart · New York). This is an open-access article distributed under the terms of the Creative Commons Attribution License. application/pdf |
| spellingShingle | Engineering::Mechanical engineering Intragastric Balloons Obesity Kaan, Hung Leng Phan, Phuoc Thien Tiong, Anthony Meng Huat Miyasaka, Muneaki Phee, Soo Jay Ho, Khek Yu First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| title | First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| title_full | First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| title_fullStr | First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| title_full_unstemmed | First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| title_short | First-in-man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| title_sort | first in man feasibility study of a novel ingestible magnetically inflated balloon capsule for treatment of obesity |
| topic | Engineering::Mechanical engineering Intragastric Balloons Obesity |
| url | https://hdl.handle.net/10356/145348 |
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