Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis
Early-onset neonatal sepsis (EOS) is a major cause of neonatal death and long-term neurodevelopmental disabilities among survivors. The common pathogens causing EOS are group B streptococcus (GBS) and Escherichia coli. Haemophilus influenzae (H. influenzae) is a Gram-negative coccobacillus that can...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/145352 |
| _version_ | 1811686915877896192 |
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| author | Chowdhury, Sudipta Roy Bharadwaj, Srabani Chandran, Suresh |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chowdhury, Sudipta Roy Bharadwaj, Srabani Chandran, Suresh |
| author_sort | Chowdhury, Sudipta Roy |
| collection | NTU |
| description | Early-onset neonatal sepsis (EOS) is a major cause of neonatal death and long-term neurodevelopmental disabilities among survivors. The common pathogens causing EOS are group B streptococcus (GBS) and Escherichia coli. Haemophilus influenzae (H. influenzae) is a Gram-negative coccobacillus that can cause severe invasive disease and can be divided into either typeable or non-typeable strains. H. influenzae serotype b (Hib) is the most virulent and the major cause of bacterial meningitis in young children prior to routine immunization against Hib. Hib infection rates have dramatically reduced since then. However, a number of studies have reported an increasing incidence of non-typeable H. influenzae (NTHi) sepsis in neonates worldwide and concluded that pregnant women may have an increased risk to invasive NTHi disease with poor pregnancy outcomes. We present a case of fulminant neonatal sepsis caused by NTHi in an extremely preterm infant and discuss potential preventative measures to reduce its re-emergence. |
| first_indexed | 2024-10-01T05:08:01Z |
| format | Journal Article |
| id | ntu-10356/145352 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:08:01Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1453522023-03-05T16:49:05Z Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis Chowdhury, Sudipta Roy Bharadwaj, Srabani Chandran, Suresh Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Non-typeable Haemophilus Influenza Early-onset Neonatal Sepsis Early-onset neonatal sepsis (EOS) is a major cause of neonatal death and long-term neurodevelopmental disabilities among survivors. The common pathogens causing EOS are group B streptococcus (GBS) and Escherichia coli. Haemophilus influenzae (H. influenzae) is a Gram-negative coccobacillus that can cause severe invasive disease and can be divided into either typeable or non-typeable strains. H. influenzae serotype b (Hib) is the most virulent and the major cause of bacterial meningitis in young children prior to routine immunization against Hib. Hib infection rates have dramatically reduced since then. However, a number of studies have reported an increasing incidence of non-typeable H. influenzae (NTHi) sepsis in neonates worldwide and concluded that pregnant women may have an increased risk to invasive NTHi disease with poor pregnancy outcomes. We present a case of fulminant neonatal sepsis caused by NTHi in an extremely preterm infant and discuss potential preventative measures to reduce its re-emergence. Published version 2020-12-18T02:33:07Z 2020-12-18T02:33:07Z 2020 Journal Article Chowdhury, S. R., Bharadwaj, S., & Chandran, S. (2020). Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis. Tropical Medicine and Infectious Disease, 5(1), 30-, doi:10.3390/tropicalmed5010030 2414-6366 https://hdl.handle.net/10356/145352 10.3390/tropicalmed5010030 32093381 1 5 en Tropical Medicine and Infectious Disease © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) application/pdf |
| spellingShingle | Science::Medicine Non-typeable Haemophilus Influenza Early-onset Neonatal Sepsis Chowdhury, Sudipta Roy Bharadwaj, Srabani Chandran, Suresh Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis |
| title | Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis |
| title_full | Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis |
| title_fullStr | Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis |
| title_full_unstemmed | Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis |
| title_short | Fatal, fulminant and invasive non-typeable Haemophilus influenzae infection in a preterm infant : a re-emerging cause of neonatal sepsis |
| title_sort | fatal fulminant and invasive non typeable haemophilus influenzae infection in a preterm infant a re emerging cause of neonatal sepsis |
| topic | Science::Medicine Non-typeable Haemophilus Influenza Early-onset Neonatal Sepsis |
| url | https://hdl.handle.net/10356/145352 |
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