Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects

Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects

Controlled release of CRISPR-Cas9 ribonucleoprotein (RNP) and codelivery with other drugs remain a challenge. We demonstrate controlled release of CRISPR-Cas9 RNP and codelivery with antitumor photosensitizer chlorin e6 (Ce6) using near-infrared (NIR)– and reducing agent–responsive nanoparticles in...

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Bibliographic Details
Main Authors: Deng, Shaohui, Li, Xiaoxia, Liu, Shuang, Chen, Jifeng, Li, Mingqiang, Chew, Sing Yian, Leong, Kam W., Cheng, Du
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Medicine
Cell Proliferation
Covalent Bonds
Online Access:https://hdl.handle.net/10356/145406

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