Linker-mediated self-assembly of mobile DNA-coated colloids
Developing construction methods of materials tailored for given applications with absolute control over building block placement poses an immense challenge. DNA-coated colloids offer the possibility of realising programmable self-assembly, which, in principle, can assemble almost any structure in eq...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2020
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| Online Access: | https://hdl.handle.net/10356/145407 |
| _version_ | 1826121642404741120 |
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| author | Xia, Xiuyang Hu, Hao Ciamarra, Massimo Pica Ni, Ran |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Xia, Xiuyang Hu, Hao Ciamarra, Massimo Pica Ni, Ran |
| author_sort | Xia, Xiuyang |
| collection | NTU |
| description | Developing construction methods of materials tailored for given applications with absolute control over building block placement poses an immense challenge. DNA-coated colloids offer the possibility of realising programmable self-assembly, which, in principle, can assemble almost any structure in equilibrium, but remains challenging experimentally. Here, we propose an innovative system of linker-mediated mobile DNA-coated colloids (mDNACCs), in which mDNACCs are bridged by the free DNA linkers in solution, whose two single-stranded DNA tails can bind with specific single-stranded DNA receptors of complementary sequence coated on colloids. We formulate a mean-field theory efficiently calculating the effective interaction between mDNACCs, where the entropy of DNA linkers plays a nontrivial role. Particularly, when the binding between free DNA linkers in solution and the corresponding receptors on mDNACCs is strong, the linker-mediated colloidal interaction is determined by the linker entropy depending on the linker concentration. |
| first_indexed | 2024-10-01T05:35:33Z |
| format | Journal Article |
| id | ntu-10356/145407 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:35:33Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1454072023-12-29T06:49:26Z Linker-mediated self-assembly of mobile DNA-coated colloids Xia, Xiuyang Hu, Hao Ciamarra, Massimo Pica Ni, Ran School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Engineering::Bioengineering Entropy Mean Field Theory Developing construction methods of materials tailored for given applications with absolute control over building block placement poses an immense challenge. DNA-coated colloids offer the possibility of realising programmable self-assembly, which, in principle, can assemble almost any structure in equilibrium, but remains challenging experimentally. Here, we propose an innovative system of linker-mediated mobile DNA-coated colloids (mDNACCs), in which mDNACCs are bridged by the free DNA linkers in solution, whose two single-stranded DNA tails can bind with specific single-stranded DNA receptors of complementary sequence coated on colloids. We formulate a mean-field theory efficiently calculating the effective interaction between mDNACCs, where the entropy of DNA linkers plays a nontrivial role. Particularly, when the binding between free DNA linkers in solution and the corresponding receptors on mDNACCs is strong, the linker-mediated colloidal interaction is determined by the linker entropy depending on the linker concentration. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Nanyang Technological University National Supercomputing Centre (NSCC) Singapore Published version We thank B. Mognetti, Q. Lei, and Y. Wang for helpful discussions. We also thank two anonymous referees for their constructive suggestions. This work has been supported, in part, by the Singapore Ministry of Education through the Academic Research Fund MOE2017-T2-1-066 (S) and (M4011873.120), by the Nanyang Technological University Start-Up Grant (NTU-SUG: M4081781.120), by the Advanced Manufacturing and Engineering Young Individual Research Grant (A1784C0018), and by the Science and Engineering Research Council of Agency for Science, Technology, and Research Singapore. We thank NSCC for granting computational resources. 2020-12-21T04:36:43Z 2020-12-21T04:36:43Z 2020 Journal Article Xia, X., Hu, H., Ciamarra, M. P., & Ni, R. (2020). Linker-mediated self-assembly of mobile DNA-coated colloids. Science Advances, 6(21), eaaz6921-. doi:10.1126/sciadv.aaz6921 2375-2548 https://hdl.handle.net/10356/145407 10.1126/sciadv.aaz6921 32637586 21 6 en MOE2017-T2-1-066 M4011873.120 M4081781.120 A1784C0018 Science Advances © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). application/pdf |
| spellingShingle | Engineering::Bioengineering Entropy Mean Field Theory Xia, Xiuyang Hu, Hao Ciamarra, Massimo Pica Ni, Ran Linker-mediated self-assembly of mobile DNA-coated colloids |
| title | Linker-mediated self-assembly of mobile DNA-coated colloids |
| title_full | Linker-mediated self-assembly of mobile DNA-coated colloids |
| title_fullStr | Linker-mediated self-assembly of mobile DNA-coated colloids |
| title_full_unstemmed | Linker-mediated self-assembly of mobile DNA-coated colloids |
| title_short | Linker-mediated self-assembly of mobile DNA-coated colloids |
| title_sort | linker mediated self assembly of mobile dna coated colloids |
| topic | Engineering::Bioengineering Entropy Mean Field Theory |
| url | https://hdl.handle.net/10356/145407 |
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