Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography
Objective: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambul...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2020
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| Online Access: | https://hdl.handle.net/10356/145432 |
| _version_ | 1824455319751753728 |
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| author | Chua, Jacqueline Chin, Calvin Woon Loong Hong, Jimmy Chee, Miao Li Le, Thu-Thao Ting, Daniel Shu Wei Wong, Tien Yin Schmetterer, Leopold |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chua, Jacqueline Chin, Calvin Woon Loong Hong, Jimmy Chee, Miao Li Le, Thu-Thao Ting, Daniel Shu Wei Wong, Tien Yin Schmetterer, Leopold |
| author_sort | Chua, Jacqueline |
| collection | NTU |
| description | Objective: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure (BP) and renal parameters. Methods: This observational cross-sectional study consisted of 153 normal eyes from 77 nondiabetic hypertensive adults [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]. Data on 24-h ambulatory BP monitoring, serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. Retinal capillary density measured with the OCT-A (AngioVue) at superficial (SVP) and deep vascular plexuses (DVP). Linear regression was used to investigate the association of risk factors with capillary density. Results: Retinal capillary density (percentage) at DVP was reduced in patients with poorly controlled BP (SBP = 148 ± 8 mmHg; 27.2 ± 13.0) compared with those with well controlled BP (SBP = 125 ± 9 mmHg; 34.7 ± 11.3). In the multivariable analysis, poorly controlled BP [β = −6.49, 95% confidence interval (CI), −12.39 to −0.59], higher SBP (β = −0.23, 95% CI −0.44 to −0.02) and lower eGFR (β = 6.42, 95% CI 1.25–11.60) were associated with sparser retinal capillary density. Systemic factors were not associated with capillary density at SVP (all P > 0.05). Conclusion: In adults with treated systemic hypertension, retinal capillary density reduced with higher BP and poorer eGFR. These findings highlight the potential role of OCT-A to study early microvascular changes because of systemic hypertension. |
| first_indexed | 2025-02-19T03:36:19Z |
| format | Journal Article |
| id | ntu-10356/145432 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:36:19Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | ntu-10356/1454322023-03-05T16:44:39Z Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography Chua, Jacqueline Chin, Calvin Woon Loong Hong, Jimmy Chee, Miao Li Le, Thu-Thao Ting, Daniel Shu Wei Wong, Tien Yin Schmetterer, Leopold Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Ambulatory Blood Pressure Monitoring Blood Pressure Objective: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure (BP) and renal parameters. Methods: This observational cross-sectional study consisted of 153 normal eyes from 77 nondiabetic hypertensive adults [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]. Data on 24-h ambulatory BP monitoring, serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. Retinal capillary density measured with the OCT-A (AngioVue) at superficial (SVP) and deep vascular plexuses (DVP). Linear regression was used to investigate the association of risk factors with capillary density. Results: Retinal capillary density (percentage) at DVP was reduced in patients with poorly controlled BP (SBP = 148 ± 8 mmHg; 27.2 ± 13.0) compared with those with well controlled BP (SBP = 125 ± 9 mmHg; 34.7 ± 11.3). In the multivariable analysis, poorly controlled BP [β = −6.49, 95% confidence interval (CI), −12.39 to −0.59], higher SBP (β = −0.23, 95% CI −0.44 to −0.02) and lower eGFR (β = 6.42, 95% CI 1.25–11.60) were associated with sparser retinal capillary density. Systemic factors were not associated with capillary density at SVP (all P > 0.05). Conclusion: In adults with treated systemic hypertension, retinal capillary density reduced with higher BP and poorer eGFR. These findings highlight the potential role of OCT-A to study early microvascular changes because of systemic hypertension. National Medical Research Council (NMRC) Published version L.S.Funding received for this workfrom National Medical Research Council (NMRC/CG/C010A/2017), Singapore. 2020-12-21T08:28:27Z 2020-12-21T08:28:27Z 2019 Journal Article Chua, J., Chin, C. W. L., Hong, J., Chee, M. L., Le, T.-T., Ting, D. S. W., . . . Schmetterer, L. (2019). Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography. Journal of Hypertension, 37(3), 572-580. doi:10.1097/hjh.0000000000001916 0263-6352 https://hdl.handle.net/10356/145432 10.1097/hjh.0000000000001916 30113530 3 37 572 580 en NMRC/CG/C010A/2017 Journal of Hypertension © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. application/pdf |
| spellingShingle | Science::Medicine Ambulatory Blood Pressure Monitoring Blood Pressure Chua, Jacqueline Chin, Calvin Woon Loong Hong, Jimmy Chee, Miao Li Le, Thu-Thao Ting, Daniel Shu Wei Wong, Tien Yin Schmetterer, Leopold Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| title | Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| title_full | Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| title_fullStr | Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| title_full_unstemmed | Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| title_short | Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| title_sort | impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography |
| topic | Science::Medicine Ambulatory Blood Pressure Monitoring Blood Pressure |
| url | https://hdl.handle.net/10356/145432 |
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