Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells.
This study has shown that ApoA-l secretion in intestinal cells is constitutive; however, the rate of apoA-l secretion is increased by as high as 5-times the constitutive secretion rate when the cells are exposed to anti-inflammatory drugs such as aspirin and paracetamol. In contrast, pro-inflammator...
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| Format: | Research Report |
| Language: | English |
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2008
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| Online Access: | http://hdl.handle.net/10356/14547 |
| _version_ | 1824456225541062656 |
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| author | Yu, Kenneth. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Yu, Kenneth. |
| author_sort | Yu, Kenneth. |
| collection | NTU |
| description | This study has shown that ApoA-l secretion in intestinal cells is constitutive; however, the rate of apoA-l secretion is increased by as high as 5-times the constitutive secretion rate when the cells are exposed to anti-inflammatory drugs such as aspirin and paracetamol. In contrast, pro-inflammatory drugs such as lipopolysaccharides and endotoxin appeared to decrease intestinal secretion of apoA-1.
These results indicate that aspirin and paracetamol, two of the most widely used medications for fevers and headaches, may have beneficial effects on the metabolism of high-density-lipoproteins(HDL),the so-called" good cholesterol" by increasing the rate of apoA-1 secretion by the intestine. This may imply that the blood concentration of HDL may increase favorably should the amount of apoA-l increase as apoA-l is a major constituent of HDL. On the other hand, a bacterial infection in the intestine that leads to inflammation caused by bacterial lipopolysaccharides and endotoxin may have an adverse effect on intestinal secretion of apoA-l, thus there may be lowered blood concentration of HDL. |
| first_indexed | 2025-02-19T03:50:43Z |
| format | Research Report |
| id | ntu-10356/14547 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:50:43Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/145472023-02-28T17:58:32Z Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. Yu, Kenneth. School of Biological Sciences DRNTU::Science::Biological sciences::Human anatomy and physiology This study has shown that ApoA-l secretion in intestinal cells is constitutive; however, the rate of apoA-l secretion is increased by as high as 5-times the constitutive secretion rate when the cells are exposed to anti-inflammatory drugs such as aspirin and paracetamol. In contrast, pro-inflammatory drugs such as lipopolysaccharides and endotoxin appeared to decrease intestinal secretion of apoA-1. These results indicate that aspirin and paracetamol, two of the most widely used medications for fevers and headaches, may have beneficial effects on the metabolism of high-density-lipoproteins(HDL),the so-called" good cholesterol" by increasing the rate of apoA-1 secretion by the intestine. This may imply that the blood concentration of HDL may increase favorably should the amount of apoA-l increase as apoA-l is a major constituent of HDL. On the other hand, a bacterial infection in the intestine that leads to inflammation caused by bacterial lipopolysaccharides and endotoxin may have an adverse effect on intestinal secretion of apoA-l, thus there may be lowered blood concentration of HDL. 2008-12-09T05:58:13Z 2008-12-09T05:58:13Z 2007 2007 Research Report http://hdl.handle.net/10356/14547 en 5 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Human anatomy and physiology Yu, Kenneth. Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. |
| title | Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. |
| title_full | Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. |
| title_fullStr | Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. |
| title_full_unstemmed | Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. |
| title_short | Effect of inflammation on apolipoprotein A-1(apoA-1) secretion by intestinal cells. |
| title_sort | effect of inflammation on apolipoprotein a 1 apoa 1 secretion by intestinal cells |
| topic | DRNTU::Science::Biological sciences::Human anatomy and physiology |
| url | http://hdl.handle.net/10356/14547 |
| work_keys_str_mv | AT yukenneth effectofinflammationonapolipoproteina1apoa1secretionbyintestinalcells |