CD4+ T cells mediate the development of liver fibrosis in high fat diet-induced NAFLD in humanized mice

CD4+ T cells mediate the development of liver fibrosis in high fat diet-induced NAFLD in humanized mice

Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chronic inflammation, and CD4+ T cell infiltration of...

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Bibliographic Details
Main Authors: Her, Zhisheng, Tan, Joel Heng Loong, Lim, Yee-Siang, Tan, Sue Yee, Chan, Xue Ying, Tan, Wilson Wei Sheng, Liu, Min, Yong, Kylie Su Mei, Lai, Fritz, Ceccarello, Erica, Zheng, Zhiqiang, Fan, Yong, Chang, Kenneth Tou En, Sun, Lei, Chang, Shih Chieh, Chin, Chih-Liang, Lee, Guan Huei, Dan, Yock Young, Chan, Yun-Shen, Lim, Seng Gee, Chan, Jerry Kok Yen, Chandy, Kanianthara George, Chen, Qingfeng
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2020
Subjects:
Science::Biological sciences
Humanized Mouse Model
NAFLD
Online Access:https://hdl.handle.net/10356/145632

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