Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and faci...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/145833 |
| _version_ | 1811680010992353280 |
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| author | Khan, Munezza Ata Mohammad Mujahid |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Khan, Munezza Ata Mohammad Mujahid |
| author_sort | Khan, Munezza Ata |
| collection | NTU |
| description | Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications. |
| first_indexed | 2024-10-01T03:18:16Z |
| format | Journal Article |
| id | ntu-10356/145833 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:18:16Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1458332023-07-14T16:02:22Z Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 Khan, Munezza Ata Mohammad Mujahid School of Materials Science and Engineering Engineering::Materials Interleukin 6 Biosensor Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications. Published version 2021-01-11T07:08:53Z 2021-01-11T07:08:53Z 2020 Journal Article Khan, M. A., & Mohammad Mujahid. (2020). Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6. Sensors, 20(3), 646-. doi:10.3390/s20030646 1424-8220 https://hdl.handle.net/10356/145833 10.3390/s20030646 31979357 3 20 en Sensors © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Engineering::Materials Interleukin 6 Biosensor Khan, Munezza Ata Mohammad Mujahid Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| title | Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| title_full | Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| title_fullStr | Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| title_full_unstemmed | Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| title_short | Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| title_sort | recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 |
| topic | Engineering::Materials Interleukin 6 Biosensor |
| url | https://hdl.handle.net/10356/145833 |
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