Lysogeny in Streptococcus pneumoniae
Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates o...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/145885 |
| _version_ | 1811676297312600064 |
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| author | Garriss, Geneviève Henriques-Normark, Birgitta |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Garriss, Geneviève Henriques-Normark, Birgitta |
| author_sort | Garriss, Geneviève |
| collection | NTU |
| description | Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates of the human pathogen Streptococcus pneumoniae are frequently lysogenic, and genomic studies have allowed the classification of these phages into distinct phylogenetic groups. Here, we review the recent advances in the characterization of temperate pneumococcal phages, with a focus on their genetic features and chromosomal integration loci. We also discuss the contribution of phages, and specific phage-encoded features, to colonization and virulence. Finally, we discuss interesting research perspectives in this field. |
| first_indexed | 2024-10-01T02:19:14Z |
| format | Journal Article |
| id | ntu-10356/145885 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:19:14Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1458852023-03-05T16:43:18Z Lysogeny in Streptococcus pneumoniae Garriss, Geneviève Henriques-Normark, Birgitta Lee Kong Chian School of Medicine (LKCMedicine) Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) Science::Biological sciences Temperate Bacteriophages Streptococcus Pneumoniae Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates of the human pathogen Streptococcus pneumoniae are frequently lysogenic, and genomic studies have allowed the classification of these phages into distinct phylogenetic groups. Here, we review the recent advances in the characterization of temperate pneumococcal phages, with a focus on their genetic features and chromosomal integration loci. We also discuss the contribution of phages, and specific phage-encoded features, to colonization and virulence. Finally, we discuss interesting research perspectives in this field. Published version 2021-01-13T06:04:05Z 2021-01-13T06:04:05Z 2020 Journal Article Garriss, G., & Henriques-Normark, B. (2020). Lysogeny in Streptococcus pneumoniae. Microorganisms, 8(10), 1546-. doi:10.3390/microorganisms8101546 2076-2607 https://hdl.handle.net/10356/145885 10.3390/microorganisms8101546 33036379 2-s2.0-85092377643 10 8 en Microorganisms © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Biological sciences Temperate Bacteriophages Streptococcus Pneumoniae Garriss, Geneviève Henriques-Normark, Birgitta Lysogeny in Streptococcus pneumoniae |
| title | Lysogeny in Streptococcus pneumoniae |
| title_full | Lysogeny in Streptococcus pneumoniae |
| title_fullStr | Lysogeny in Streptococcus pneumoniae |
| title_full_unstemmed | Lysogeny in Streptococcus pneumoniae |
| title_short | Lysogeny in Streptococcus pneumoniae |
| title_sort | lysogeny in streptococcus pneumoniae |
| topic | Science::Biological sciences Temperate Bacteriophages Streptococcus Pneumoniae |
| url | https://hdl.handle.net/10356/145885 |
| work_keys_str_mv | AT garrissgenevieve lysogenyinstreptococcuspneumoniae AT henriquesnormarkbirgitta lysogenyinstreptococcuspneumoniae |