A human antibody neutralizes different flaviviruses by using different mechanisms

A human antibody neutralizes different flaviviruses by using different mechanisms

Human antibody SIgN-3C neutralizes dengue virus (DENV) and Zika virus (ZIKV) differently. DENV:SIgN-3C Fab and ZIKV:SIgN-3C Fab cryoelectron microscopy (cryo-EM) complex structures show Fabs crosslink E protein dimers at extracellular pH 8.0 condition and also when further incubated at acidic endoso...

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Bibliographic Details
Main Authors:	Zhang, Shuijun, Loy, Thomas, Ng, Thiam-Seng, Lim, Xin-Ni, Chew, Valerie Shyn-Yun, Tan, Ter Yong, Xu, Meihui, Kostyuchenko, Victor A., Tukijan, Farhana, Shi, Jian, Fink, Katja, Lok, Shee-Mei
Other Authors:	School of Biological Sciences
Format:	Journal Article
Language:	English
Published:	2021
Subjects:	Science::Biological sciences Dengue Virus Zika Virus
Online Access:	https://hdl.handle.net/10356/145978

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