Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves

Patterning and manipulating of living cells and microparticles have tremendous potential applications in microfluidics, biology, tissue engineering and material assembling. Among many possible techniques, the technology based on surface acoustic waves (SAWs) has attracted many attentions owing to it...

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Main Author: Nguyen, Tan Dai
Other Authors: Du Hejun
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2021
Subjects:
Online Access:https://hdl.handle.net/10356/146006
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author Nguyen, Tan Dai
author2 Du Hejun
author_facet Du Hejun
Nguyen, Tan Dai
author_sort Nguyen, Tan Dai
collection NTU
description Patterning and manipulating of living cells and microparticles have tremendous potential applications in microfluidics, biology, tissue engineering and material assembling. Among many possible techniques, the technology based on surface acoustic waves (SAWs) has attracted many attentions owing to its good biocompatibility, low-power consumption, autonomy capability, nature of non-invasive and non-contact. SAWs have been proved to present outstanding performance in the manipulation of a single and group of cells or microparticles inside the polydimethylsiloxane (PDMS) microfluidic channels. However, most of SAW microfluidic devices reported so far had two major limitations, 1) the lack of capability of three dimensional (3D) manipulating and patterning; 2) the lack of precise and reliable controls. Those limitations need to be overcome in order to develop an efficient and automated system where the biological cells can be precisely manipulated in three dimensions. Hence, this research aims to investigate and develop the technology for three-dimensional patterning and manipulating of microparticles and cells through advanced design and implementation of a closed-loop control strategy in SAW-based microfluidic devices.
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spelling ntu-10356/1460062023-03-11T17:35:23Z Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves Nguyen, Tan Dai Du Hejun School of Mechanical and Aerospace Engineering MHDU@ntu.edu.sg Engineering::Mechanical engineering Patterning and manipulating of living cells and microparticles have tremendous potential applications in microfluidics, biology, tissue engineering and material assembling. Among many possible techniques, the technology based on surface acoustic waves (SAWs) has attracted many attentions owing to its good biocompatibility, low-power consumption, autonomy capability, nature of non-invasive and non-contact. SAWs have been proved to present outstanding performance in the manipulation of a single and group of cells or microparticles inside the polydimethylsiloxane (PDMS) microfluidic channels. However, most of SAW microfluidic devices reported so far had two major limitations, 1) the lack of capability of three dimensional (3D) manipulating and patterning; 2) the lack of precise and reliable controls. Those limitations need to be overcome in order to develop an efficient and automated system where the biological cells can be precisely manipulated in three dimensions. Hence, this research aims to investigate and develop the technology for three-dimensional patterning and manipulating of microparticles and cells through advanced design and implementation of a closed-loop control strategy in SAW-based microfluidic devices. Doctor of Philosophy 2021-01-21T01:27:03Z 2021-01-21T01:27:03Z 2020 Thesis-Doctor of Philosophy Nguyen, T. D. (2020). Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves. S Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/146006 10.32657/10356/146006 en The Academic Research Fund (AcRF) Tier 1 grants (RG 96/18) https://hdl.handle.net/10356/83137 https://hdl.handle.net/10356/137474 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University
spellingShingle Engineering::Mechanical engineering
Nguyen, Tan Dai
Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
title Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
title_full Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
title_fullStr Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
title_full_unstemmed Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
title_short Multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
title_sort multidimensional patterning and manipulating of microparticles and cells using surface acoustic waves
topic Engineering::Mechanical engineering
url https://hdl.handle.net/10356/146006
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