Reduction of mNAT1/hNAT2 contributes to cerebral endothelial necroptosis and Aβ accumulation in alzheimer's disease

Reduction of mNAT1/hNAT2 contributes to cerebral endothelial necroptosis and Aβ accumulation in alzheimer's disease

The contribution and mechanism of cerebrovascular pathology in Alzheimer's disease (AD) pathogenesis are still unclear. Here, we show that venular and capillary cerebral endothelial cells (ECs) are selectively vulnerable to necroptosis in AD. We identify reduced cerebromicrovascular expression...

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Bibliographic Details
Main Authors: Zou, Chengyu, Mifflin, Lauren, Hu, Zhirui, Zhang, Tian, Shan, Bing, Wang, Huibing, Xing, Xin, Zhu, Hong, Adiconis, Xian, Levin, Joshua Z., Li, Fupeng, Liu, Chuan-Fa, Liu, Jun S., Yuan, Junying
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Necroptosis
Alzheimer’s Disease
Online Access:https://hdl.handle.net/10356/146010

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