Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination
Coordinated nonreciprocal dynamics in biological cilia is essential to many living systems, where the emergentmetachronal waves of cilia have been hypothesized to enhance net fluid flows at low Reynolds numbers (Re). Experimental investigation of this hypothesis is critical but remains challenging....
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/146076 |
| _version_ | 1826110364571402240 |
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| author | Dong, Xiaoguang Lum, Guo Zhan Hu, Wenqi Zhang, Rongjing Ren, Ziyu Onck, Patrick R. Sitti, Metin |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Dong, Xiaoguang Lum, Guo Zhan Hu, Wenqi Zhang, Rongjing Ren, Ziyu Onck, Patrick R. Sitti, Metin |
| author_sort | Dong, Xiaoguang |
| collection | NTU |
| description | Coordinated nonreciprocal dynamics in biological cilia is essential to many living systems, where the emergentmetachronal waves of cilia have been hypothesized to enhance net fluid flows at low Reynolds numbers (Re). Experimental investigation of this hypothesis is critical but remains challenging. Here, we report soft miniature devices with both ciliary nonreciprocal motion and metachronal coordination and use them to investigate the quantitative relationship between metachronal coordination and the induced fluid flow. We found that only antiplectic metachronal waves with specific wave vectors could enhance fluid flows compared with the synchronized case. These findings further enable various bioinspired cilia arrays with unique functionalities of pumping and mixing viscous synthetic and biological complex fluids at low Re Our design method and developed soft miniature devices provide unprecedented opportunities for studying ciliary biomechanics and creating cilia-inspired wireless microfluidic pumping, object manipulation and lab- and organ-on-a-chip devices, mobile microrobots, and bioengineering systems. |
| first_indexed | 2024-10-01T02:33:12Z |
| format | Journal Article |
| id | ntu-10356/146076 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:33:12Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1460762023-03-04T17:22:21Z Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination Dong, Xiaoguang Lum, Guo Zhan Hu, Wenqi Zhang, Rongjing Ren, Ziyu Onck, Patrick R. Sitti, Metin School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering Miniature Instruments Reynolds Number Coordinated nonreciprocal dynamics in biological cilia is essential to many living systems, where the emergentmetachronal waves of cilia have been hypothesized to enhance net fluid flows at low Reynolds numbers (Re). Experimental investigation of this hypothesis is critical but remains challenging. Here, we report soft miniature devices with both ciliary nonreciprocal motion and metachronal coordination and use them to investigate the quantitative relationship between metachronal coordination and the induced fluid flow. We found that only antiplectic metachronal waves with specific wave vectors could enhance fluid flows compared with the synchronized case. These findings further enable various bioinspired cilia arrays with unique functionalities of pumping and mixing viscous synthetic and biological complex fluids at low Re Our design method and developed soft miniature devices provide unprecedented opportunities for studying ciliary biomechanics and creating cilia-inspired wireless microfluidic pumping, object manipulation and lab- and organ-on-a-chip devices, mobile microrobots, and bioengineering systems. Published version 2021-01-25T09:05:57Z 2021-01-25T09:05:57Z 2020 Journal Article Dong, X., Lum, G. Z., Hu, W., Zhang, R., Ren, Z., Onck, P. R., & Sitti, M. (2020). Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination. Science Advances, 6(45), eabc9323-. doi:10.1126/sciadv.abc9323 2375-2548 https://hdl.handle.net/10356/146076 10.1126/sciadv.abc9323 33158868 45 6 en Science Advances © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). application/pdf |
| spellingShingle | Engineering::Mechanical engineering Miniature Instruments Reynolds Number Dong, Xiaoguang Lum, Guo Zhan Hu, Wenqi Zhang, Rongjing Ren, Ziyu Onck, Patrick R. Sitti, Metin Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| title | Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| title_full | Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| title_fullStr | Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| title_full_unstemmed | Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| title_short | Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| title_sort | bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination |
| topic | Engineering::Mechanical engineering Miniature Instruments Reynolds Number |
| url | https://hdl.handle.net/10356/146076 |
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