Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier

Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier

Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. The...

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Bibliographic Details
Main Authors: Gallego-Delgado, Patricia, James, Rachel, Browne, Eleanor, Meng, Joanna, Umashankar, Swetha, Tan, Li, Picon, Carmen, Mazarakis, Nicholas D., Faisal, A. Aldo, Howell, Owain W., Reynolds, Richard
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Multiple Sclerosis
Axon Stress
Online Access:https://hdl.handle.net/10356/146129

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