The neutrally charged diarylurea compound PQ401 kills antibiotic-resistant and antibiotic-tolerant Staphylococcus aureus

The neutrally charged diarylurea compound PQ401 kills antibiotic-resistant and antibiotic-tolerant Staphylococcus aureus

Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, traditional bactericidal antibiotics kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant to and therefore "persist" in the...

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Bibliographic Details
Main Authors: Kim, Wooseong, Zou, Guijin, Pan, Wen, Fricke, Nico, Faizi, Hammad A., Kim, Soo Min, Khader, Rajamohammed, Li, Silei, Lee, Kiho, Escorba, Iliana, Vlahovska, Petia M., Gao, Huajian, Ausubel, Frederick M., Mylonakis, Eleftherios
Other Authors: School of Mechanical and Aerospace Engineering
Format: Journal Article
Language:English
Published: 2021
Subjects:
Engineering::Mechanical engineering
Persisters
Antibiotic Tolerance
Online Access:https://hdl.handle.net/10356/146178

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