Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore
Respiratory syncytial virus (RSV) is the most common cause of pediatric acute lower respiratory tract infection worldwide. Detailed data on the health and economic burden of RSV disease are lacking from tropical settings with year-round RSV transmission. We developed a statistical and economic model...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/146333 |
| _version_ | 1811696502119071744 |
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| author | Tam, Clarence C. Yeo, Kee Thai Tee, Nancy Lin, Raymond Mak, Tze Minn Thoon, Koh Cheng Jit, Mark Yung, Chee Fu |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tam, Clarence C. Yeo, Kee Thai Tee, Nancy Lin, Raymond Mak, Tze Minn Thoon, Koh Cheng Jit, Mark Yung, Chee Fu |
| author_sort | Tam, Clarence C. |
| collection | NTU |
| description | Respiratory syncytial virus (RSV) is the most common cause of pediatric acute lower respiratory tract infection worldwide. Detailed data on the health and economic burden of RSV disease are lacking from tropical settings with year-round RSV transmission. We developed a statistical and economic model to estimate the annual incidence and healthcare cost of medically attended RSV disease among young children in Singapore, using Monte Carlo simulation to account for uncertainty in model parameters. RSV accounted for 708 hospitalizations in children <6 months of age (33.5/1,000 child-years) and 1,096 in children 6-29 months of age (13.2/1,000 child-years). The cost of hospitalization was SGD 5.7 million (US $4.3 million) at 2014 prices; patients bore 60% of the cost. RSV-associated disease burden in tropical settings in Asia is high and comparable to other settings. Further work incorporating efficacy data from ongoing vaccine trials will help to determine the potential cost-effectiveness of different vaccination strategies. |
| first_indexed | 2024-10-01T07:40:23Z |
| format | Journal Article |
| id | ntu-10356/146333 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:40:23Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1463332023-03-05T16:43:39Z Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore Tam, Clarence C. Yeo, Kee Thai Tee, Nancy Lin, Raymond Mak, Tze Minn Thoon, Koh Cheng Jit, Mark Yung, Chee Fu Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Bronchiolitis Disease Burden Respiratory syncytial virus (RSV) is the most common cause of pediatric acute lower respiratory tract infection worldwide. Detailed data on the health and economic burden of RSV disease are lacking from tropical settings with year-round RSV transmission. We developed a statistical and economic model to estimate the annual incidence and healthcare cost of medically attended RSV disease among young children in Singapore, using Monte Carlo simulation to account for uncertainty in model parameters. RSV accounted for 708 hospitalizations in children <6 months of age (33.5/1,000 child-years) and 1,096 in children 6-29 months of age (13.2/1,000 child-years). The cost of hospitalization was SGD 5.7 million (US $4.3 million) at 2014 prices; patients bore 60% of the cost. RSV-associated disease burden in tropical settings in Asia is high and comparable to other settings. Further work incorporating efficacy data from ongoing vaccine trials will help to determine the potential cost-effectiveness of different vaccination strategies. Published version 2021-02-09T08:04:51Z 2021-02-09T08:04:51Z 2020 Journal Article Tam, C. C., Yeo, K. T., Tee, N., Lin, R., Mak, T. M., Thoon, K. C., . . . Yung, C. F. (2020). Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore. Emerging Infectious Diseases, 26(7), 1489-1496. doi:10.3201/eid2607.190539 1080-6040 https://hdl.handle.net/10356/146333 10.3201/eid2607.190539 32568036 2-s2.0-85086867499 7 26 1489 1496 en Emerging Infectious Diseases © 2020 The Author(s) (published by Public Domain). This is an open-access article distributed under the terms of the Creative Commons Attribution License. application/pdf |
| spellingShingle | Science::Medicine Bronchiolitis Disease Burden Tam, Clarence C. Yeo, Kee Thai Tee, Nancy Lin, Raymond Mak, Tze Minn Thoon, Koh Cheng Jit, Mark Yung, Chee Fu Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore |
| title | Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore |
| title_full | Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore |
| title_fullStr | Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore |
| title_full_unstemmed | Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore |
| title_short | Burden and cost of hospitalization for respiratory syncytial virus in young children, Singapore |
| title_sort | burden and cost of hospitalization for respiratory syncytial virus in young children singapore |
| topic | Science::Medicine Bronchiolitis Disease Burden |
| url | https://hdl.handle.net/10356/146333 |
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