Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study
(1) Background: Breastfeeding has been shown to support glucose homeostasis in women after a pregnancy complicated by gestational diabetes mellitus (GDM) and is potentially effective at reducing long-term diabetes risk. (2) Methods: Data from the Growing Up in Singapore Towards healthy Outcomes (GUS...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/146417 |
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| author | Hewage, Sumali S. Koh, Hazel Xin Yu Soh, Shu E. Pang, Wei Wei Fok, Doris Cai, Shirong Müller-Riemenschneider, Falk Yap, Fabian Tan, Kok Hian Chua, Mei Chien Lim, Sok Bee Godfrey, Keith M. Colega, Marjorelee T. Chong, Yap-Seng Chan, Shiao-Yng Yoong, Joanne Chong, Mary F. F. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Hewage, Sumali S. Koh, Hazel Xin Yu Soh, Shu E. Pang, Wei Wei Fok, Doris Cai, Shirong Müller-Riemenschneider, Falk Yap, Fabian Tan, Kok Hian Chua, Mei Chien Lim, Sok Bee Godfrey, Keith M. Colega, Marjorelee T. Chong, Yap-Seng Chan, Shiao-Yng Yoong, Joanne Chong, Mary F. F. |
| author_sort | Hewage, Sumali S. |
| collection | NTU |
| description | (1) Background: Breastfeeding has been shown to support glucose homeostasis in women after a pregnancy complicated by gestational diabetes mellitus (GDM) and is potentially effective at reducing long-term diabetes risk. (2) Methods: Data from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study were analyzed to understand the influence of breastfeeding duration on long-term dysglycemia (prediabetes and diabetes) risk in women who had GDM in the index pregnancy. GDM and dysglycemia four to seven years postpartum were determined by the oral glucose tolerance test (OGTT). A Poisson regression model with a robust error variance was used to estimate incidence rate ratios (IRRs) for dysglycemia four to seven years post-delivery according to groupings of the duration of any breastfeeding (<1, ≥1 to <6, and ≥6 months). (3) Results: Women who had GDM during the index pregnancy and complete breastfeeding information and OGTT four to seven years postpartum were included in this study (n = 116). Fifty-one women (44%) had postpartum dysglycemia. Unadjusted IRRs showed an inverse association between dysglycemia risk and ≥1 month to <6 months (IRR 0.91; 95% confidence interval [CI] 0.57, 1.43; p = 0.68) and ≥6 months (IRR 0.50; 95% CI 0.27, 0.91; p = 0.02) breastfeeding compared to <1 month of any breastfeeding. After adjusting for key confounders, the IRR for the ≥6 months group remained significant (IRR 0.42; 95% CI 0.22, 0.80; p = 0.008). (4) Conclusions: Our results suggest that any breastfeeding of six months or longer may reduce long-term dysglycemia risk in women with a history of GDM in an Asian setting. Breastfeeding has benefits for mothers beyond weight loss, particularly for those with GDM. |
| first_indexed | 2024-10-01T03:39:35Z |
| format | Journal Article |
| id | ntu-10356/146417 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:39:35Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1464172023-03-05T16:44:34Z Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study Hewage, Sumali S. Koh, Hazel Xin Yu Soh, Shu E. Pang, Wei Wei Fok, Doris Cai, Shirong Müller-Riemenschneider, Falk Yap, Fabian Tan, Kok Hian Chua, Mei Chien Lim, Sok Bee Godfrey, Keith M. Colega, Marjorelee T. Chong, Yap-Seng Chan, Shiao-Yng Yoong, Joanne Chong, Mary F. F. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Breastfeeding Gestational Diabetes (1) Background: Breastfeeding has been shown to support glucose homeostasis in women after a pregnancy complicated by gestational diabetes mellitus (GDM) and is potentially effective at reducing long-term diabetes risk. (2) Methods: Data from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study were analyzed to understand the influence of breastfeeding duration on long-term dysglycemia (prediabetes and diabetes) risk in women who had GDM in the index pregnancy. GDM and dysglycemia four to seven years postpartum were determined by the oral glucose tolerance test (OGTT). A Poisson regression model with a robust error variance was used to estimate incidence rate ratios (IRRs) for dysglycemia four to seven years post-delivery according to groupings of the duration of any breastfeeding (<1, ≥1 to <6, and ≥6 months). (3) Results: Women who had GDM during the index pregnancy and complete breastfeeding information and OGTT four to seven years postpartum were included in this study (n = 116). Fifty-one women (44%) had postpartum dysglycemia. Unadjusted IRRs showed an inverse association between dysglycemia risk and ≥1 month to <6 months (IRR 0.91; 95% confidence interval [CI] 0.57, 1.43; p = 0.68) and ≥6 months (IRR 0.50; 95% CI 0.27, 0.91; p = 0.02) breastfeeding compared to <1 month of any breastfeeding. After adjusting for key confounders, the IRR for the ≥6 months group remained significant (IRR 0.42; 95% CI 0.22, 0.80; p = 0.008). (4) Conclusions: Our results suggest that any breastfeeding of six months or longer may reduce long-term dysglycemia risk in women with a history of GDM in an Asian setting. Breastfeeding has benefits for mothers beyond weight loss, particularly for those with GDM. Agency for Science, Technology and Research (A*STAR) Ministry of Health (MOH) National Medical Research Council (NMRC) National Research Foundation (NRF) Published version This research was supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore (NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014). Additional funding was provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. 2021-02-16T07:58:20Z 2021-02-16T07:58:20Z 2021 Journal Article Hewage, S. S., Koh, H. X. Y., Soh, S. E., Pang, W. W., Fok, D., Cai, S., . . . Chong, M. F. F. (2021). Breastfeeding Duration and Development of Dysglycemia in Women Who Had Gestational Diabetes Mellitus: Evidence from the GUSTO Cohort Study. Nutrients, 13(2), 408-. doi:10.3390/nu13020408 2072-6643 https://hdl.handle.net/10356/146417 10.3390/nu13020408 33525398 2-s2.0-85099803177 2 13 en NMRC/TCR/004-NUS/2008 NMRC/TCR/012-NUHS/2014 Nutrients © 2021 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Breastfeeding Gestational Diabetes Hewage, Sumali S. Koh, Hazel Xin Yu Soh, Shu E. Pang, Wei Wei Fok, Doris Cai, Shirong Müller-Riemenschneider, Falk Yap, Fabian Tan, Kok Hian Chua, Mei Chien Lim, Sok Bee Godfrey, Keith M. Colega, Marjorelee T. Chong, Yap-Seng Chan, Shiao-Yng Yoong, Joanne Chong, Mary F. F. Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study |
| title | Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study |
| title_full | Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study |
| title_fullStr | Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study |
| title_full_unstemmed | Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study |
| title_short | Breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus : evidence from the GUSTO cohort study |
| title_sort | breastfeeding duration and development of dysglycemia in women who had gestational diabetes mellitus evidence from the gusto cohort study |
| topic | Science::Medicine Breastfeeding Gestational Diabetes |
| url | https://hdl.handle.net/10356/146417 |
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