Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics
Near-infrared (NIR) biophotonics-based smart photon-converting systems (PCSs) have made great process in recent biomedical applications, such as optical imaging and phototheranostics. Owing to the versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in practical...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/146458 |
| _version_ | 1811697392016162816 |
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| author | Wang, Zhimin |
| author2 | Xing Bengang |
| author_facet | Xing Bengang Wang, Zhimin |
| author_sort | Wang, Zhimin |
| collection | NTU |
| description | Near-infrared (NIR) biophotonics-based smart photon-converting systems (PCSs) have made great process in recent biomedical applications, such as optical imaging and phototheranostics. Owing to the versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in practical operations, these NIR-responsive platforms provide opportunities to deeply investigate the physiopathological and therapeutic aspects from cells to the organism level. In principle, the design of NIR-biophotonic PCSs is primarily based on the photophysical process and physicochemical properties of the optical materials upon light irradiation, and the mechanisms include the radiative/nonradiative transitions-mediated photon emission, heat generation as well as the cascade energy transfer. In this thesis, I focus on the development of unique NIR PCSs on the basis of upconversion nanoparticles (UCNPs), cyanine dyes and charge-transfer nanocomplexes (CTNs) for multipurpose biophotonic utilizations including liver pathological/pharmacological screening, tumor phototheranostics, bacterial infection imaging and optogenetic regulation of insulin resistance. |
| first_indexed | 2024-10-01T07:54:31Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/146458 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:54:31Z |
| publishDate | 2021 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1464582023-02-28T23:55:55Z Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics Wang, Zhimin Xing Bengang School of Physical and Mathematical Sciences Bengang@ntu.edu.sg Science::Chemistry::Biochemistry Near-infrared (NIR) biophotonics-based smart photon-converting systems (PCSs) have made great process in recent biomedical applications, such as optical imaging and phototheranostics. Owing to the versatile manipulability, superb spatiotemporal precision and minimal tissue invasiveness in practical operations, these NIR-responsive platforms provide opportunities to deeply investigate the physiopathological and therapeutic aspects from cells to the organism level. In principle, the design of NIR-biophotonic PCSs is primarily based on the photophysical process and physicochemical properties of the optical materials upon light irradiation, and the mechanisms include the radiative/nonradiative transitions-mediated photon emission, heat generation as well as the cascade energy transfer. In this thesis, I focus on the development of unique NIR PCSs on the basis of upconversion nanoparticles (UCNPs), cyanine dyes and charge-transfer nanocomplexes (CTNs) for multipurpose biophotonic utilizations including liver pathological/pharmacological screening, tumor phototheranostics, bacterial infection imaging and optogenetic regulation of insulin resistance. Doctor of Philosophy 2021-02-18T00:57:14Z 2021-02-18T00:57:14Z 2020 Thesis-Doctor of Philosophy Wang, Z. (2020). Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/146458 10.32657/10356/146458 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Science::Chemistry::Biochemistry Wang, Zhimin Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics |
| title | Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics |
| title_full | Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics |
| title_fullStr | Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics |
| title_full_unstemmed | Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics |
| title_short | Near-infrared photon-converting systems for bioimaging, theranostics and optogenetics |
| title_sort | near infrared photon converting systems for bioimaging theranostics and optogenetics |
| topic | Science::Chemistry::Biochemistry |
| url | https://hdl.handle.net/10356/146458 |
| work_keys_str_mv | AT wangzhimin nearinfraredphotonconvertingsystemsforbioimagingtheranosticsandoptogenetics |