In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system
Assessment of morphological changes in cerebral venous sinus of small animal models is important to gain insights of various disease conditions such as intracranial hypotension, Idiopathic intracranial hypertension (IIH), Cerebral venous sinus thrombosis, subdural hematoma etc. Photoacoustic Tomogra...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/146565 |
| _version_ | 1826125517044056064 |
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| author | Rajendran, Praveenbalaji Sahu, Samiran Dienzo, Rhonnie Austria Pramanik, Manojit |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Rajendran, Praveenbalaji Sahu, Samiran Dienzo, Rhonnie Austria Pramanik, Manojit |
| author_sort | Rajendran, Praveenbalaji |
| collection | NTU |
| description | Assessment of morphological changes in cerebral venous sinus of small animal models is important to gain insights of various disease conditions such as intracranial hypotension, Idiopathic intracranial hypertension (IIH), Cerebral venous sinus thrombosis, subdural hematoma etc. Photoacoustic Tomography (PAT), a fast-growing non-invasive hybrid imaging modality which combines high optical contrast and resolution in deep tissue imaging offers a novel, rapid and cost-effective way to analyze the morphological changes of venous sinus in comparison with the conventional imaging modalities. In this study, we examined the morphological changes of sagittal sinus in the rat brain due to intracranial pressure changes induced by Cerebrospinal fluid (CSF) extraction using low cost pulsed laser diode (PLD) based desktop (PAT) system. Our results indicate that the desktop PLD-PAT system can be employed to evaluate the changes in the cerebral venous sinus in preclinical models. We observed a ∼30% average increase in the area of sagittal venous sinus from the baseline, when the CSF is extracted. |
| first_indexed | 2024-10-01T06:37:36Z |
| format | Conference Paper |
| id | ntu-10356/146565 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:37:36Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1465652023-12-29T06:44:12Z In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system Rajendran, Praveenbalaji Sahu, Samiran Dienzo, Rhonnie Austria Pramanik, Manojit School of Chemical and Biomedical Engineering SPIE - Photons Plus Ultrasound: Imaging and Sensing 2020 Engineering::Bioengineering Photoacoustic Imaging Cerebral Venous Sinus Assessment of morphological changes in cerebral venous sinus of small animal models is important to gain insights of various disease conditions such as intracranial hypotension, Idiopathic intracranial hypertension (IIH), Cerebral venous sinus thrombosis, subdural hematoma etc. Photoacoustic Tomography (PAT), a fast-growing non-invasive hybrid imaging modality which combines high optical contrast and resolution in deep tissue imaging offers a novel, rapid and cost-effective way to analyze the morphological changes of venous sinus in comparison with the conventional imaging modalities. In this study, we examined the morphological changes of sagittal sinus in the rat brain due to intracranial pressure changes induced by Cerebrospinal fluid (CSF) extraction using low cost pulsed laser diode (PLD) based desktop (PAT) system. Our results indicate that the desktop PLD-PAT system can be employed to evaluate the changes in the cerebral venous sinus in preclinical models. We observed a ∼30% average increase in the area of sagittal venous sinus from the baseline, when the CSF is extracted. Accepted version 2021-03-01T07:07:58Z 2021-03-01T07:07:58Z 2020 Conference Paper Rajendran, P., Sahu, S., Dienzo, R. A., & Pramanik, M. (2020). In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system. Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2020, 11240, 107-. doi:10.1117/12.2543892 9781510632431 https://hdl.handle.net/10356/146565 10.1117/12.2543892 2-s2.0-85082726970 11240 107 en Copyright 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. application/pdf |
| spellingShingle | Engineering::Bioengineering Photoacoustic Imaging Cerebral Venous Sinus Rajendran, Praveenbalaji Sahu, Samiran Dienzo, Rhonnie Austria Pramanik, Manojit In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system |
| title | In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system |
| title_full | In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system |
| title_fullStr | In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system |
| title_full_unstemmed | In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system |
| title_short | In vivo evaluation of cerebral venous sinus morphology using pulsed-laser-diode-based desktop photoacoustic tomography system |
| title_sort | in vivo evaluation of cerebral venous sinus morphology using pulsed laser diode based desktop photoacoustic tomography system |
| topic | Engineering::Bioengineering Photoacoustic Imaging Cerebral Venous Sinus |
| url | https://hdl.handle.net/10356/146565 |
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