Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study
Background: To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods: A cross-sectional observational study...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/146586 |
| _version_ | 1811684967779926016 |
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| author | Kee, A. R. Yip, V. C. H. Tay, E. L. T. Lim, C. W. Cheng, J. Teo, H. Y. Chua, C. H. Yip, Leonard W. L. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Kee, A. R. Yip, V. C. H. Tay, E. L. T. Lim, C. W. Cheng, J. Teo, H. Y. Chua, C. H. Yip, Leonard W. L. |
| author_sort | Kee, A. R. |
| collection | NTU |
| description | Background: To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods: A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results: A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions: AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma. |
| first_indexed | 2024-10-01T04:37:03Z |
| format | Journal Article |
| id | ntu-10356/146586 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:37:03Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1465862023-03-05T16:49:53Z Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study Kee, A. R. Yip, V. C. H. Tay, E. L. T. Lim, C. W. Cheng, J. Teo, H. Y. Chua, C. H. Yip, Leonard W. L. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Optical Coherence Tomography Angiography AngioVue Background: To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods: A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results: A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions: AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma. Published version 2021-03-02T04:19:00Z 2021-03-02T04:19:00Z 2020 Journal Article Kee, A. R., Yip, V. C. H., Tay, E. L. T., Lim, C. W., Cheng, J., Teo, H. Y., . . . Yip, L. W. L. (2020). Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study. BMC Ophthalmology, 20(1), 440-. doi:10.1186/s12886-020-01701-9 1471-2415 https://hdl.handle.net/10356/146586 10.1186/s12886-020-01701-9 33167902 2-s2.0-85095696925 1 20 en BMC Ophthalmology © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
| spellingShingle | Science::Medicine Optical Coherence Tomography Angiography AngioVue Kee, A. R. Yip, V. C. H. Tay, E. L. T. Lim, C. W. Cheng, J. Teo, H. Y. Chua, C. H. Yip, Leonard W. L. Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study |
| title | Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study |
| title_full | Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study |
| title_fullStr | Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study |
| title_full_unstemmed | Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study |
| title_short | Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes - an observational cross-sectional study |
| title_sort | comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes an observational cross sectional study |
| topic | Science::Medicine Optical Coherence Tomography Angiography AngioVue |
| url | https://hdl.handle.net/10356/146586 |
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