K13-mediated reduced susceptibility to artemisinin in Plasmodium falciparum is overlaid on a trait of enhanced DNA damage repair

K13-mediated reduced susceptibility to artemisinin in Plasmodium falciparum is overlaid on a trait of enhanced DNA damage repair

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Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with artemisinin resistance, a range of evidence suggests that...

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Bibliographic Details
Main Authors: Xiong, Aoli, Prakash, Prem, Gao, Xiaohong, Chew, Marvin, Tay, Ian Jun Jie, Woodrow, Charles J., Engelward, Bevin P., Han, Jongyoon, Preiser, Peter Rainer
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Artemisinin
K13 Protein
Online Access:https://hdl.handle.net/10356/146590

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