Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

In response to physiological demand, the pituitary gland generates new hormone-secreting cells from committed progenitor cells throughout life. It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither th...

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Bibliographic Details
Main Authors: Russell, John P., Lim, Xinhong, Santambrogio, Alice, Yianni, Val, Kemkem, Yasmine, Wang, Bruce, Fish, Matthew, Haston, Scott, Grabek, Anaëlle, Hallang, Shirleen, Lodge, Emily J., Patist, Amanda L., Schedl, Andreas, Mollard, Patrice, Nusse, Roel, Andoniadou, Cynthia L.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Medicine
Stem Cells
SOX2
Online Access:https://hdl.handle.net/10356/146869

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